Enniatin A

• 常用名: Enniatin A
• 英文名: Enniatin A
• CAS号: 2503-13-1
• 分子量: 681.90000
• 密度: 1.022±0.06 g/cm3
• 沸点: 847.4±65.0 °C
• 分子式: C₃₆H₆₃N₃O₉
• 熔点: 122-124 °C
• 闪点: N/A
• 符号: GHS06
• 信号词: Danger

Enniatin A用途

Enniatin A 是一种镰刀菌毒素。在大鼠肝微粒体酶实验中,Enniatin A 抑制酰基辅酶 A：胆固醇酰基转移酶 (ACAT) 活性,IC50 为 22 μM。

Enniatin A名称

• 中文名: 恩镰孢菌素A
• 英文名: enniatin A

Enniatin A生物活性

• 描述: Enniatin A 是一种镰刀菌毒素。在大鼠肝微粒体酶实验中,Enniatin A 抑制酰基辅酶 A：胆固醇酰基转移酶 (ACAT) 活性,IC50 为 22 μM。
• 相关类别:
  研究领域 >> 心血管疾病
  研究领域 >> 感染
  信号通路 >> 代谢酶/蛋白酶 >> 酰基转移酶
• 靶点实验:

  ACAT

• 体外研究: Enniatin A在HeLa细胞系中表现出细胞毒性作用,IC50为1.15μM浓度24小时,0.57μM浓度48小时[2]。
• 参考文献:

  [1]. Tomoda H, et al. Inhibition of acyl-CoA: cholesterol acyltransferase activity by cyclodepsipeptide antibiotics. J Antibiot (Tokyo). 1992 Oct;45(10):1626-32.

  [2]. Mamur S, et al. Assessment of cytotoxic and genotoxic effects of enniatin-A in vitro. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2018 Aug;35(8):1633-1644.

Enniatin A物理化学性质

• 密度: 1.022±0.06 g/cm3
• 沸点: 847.4±65.0 °C
• 熔点: 122-124 °C
• 分子式: C₃₆H₆₃N₃O₉
• 分子量: 681.90000
• 精确质量: 681.45600
• PSA: 139.83000
• LogP: 4.13640
• InChIKey: TWHBYJSVDCWICV-BHZTXFQCSA-N
• SMILES: CCC(C)C1C(=O)OC(C(C)C)C(=O)N(C)C(C(C)CC)C(=O)OC(C(C)C)C(=O)N(C)C(C(C)CC)C(=O)OC(C(C)C)C(=O)N1C
• 外观性状: 浅白色-白色固体
• 蒸汽压: 5.53E-29mmHg at 25°C
• 储存条件: -20°C，干燥，密封

Enniatin A安全信息

• 符号: GHS06
• 信号词: Danger
• 危害声明: H301-H311-H331
• 警示性声明: P261-P280-P301 + P310-P311
• 危害码 (欧洲): T
• 风险声明 (欧洲): 23/24/25
• 危险品运输编码: UN 2811

Enniatin A靶点实验

查看更多实验

实验名称：Induction of heat shock response in mouse 4T1 cells assessed as change in Hsp70 level... 来源：ChEMBL 靶标：4T1 External Id：CHEMBL5393299

实验名称：Inhibition of HSP90 in mouse 4T1 cells assessed as reduction in ILK level at 7.5 uM i... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5393298

实验名称：Induction of heat shock response in mouse EO771 cells assessed as change in Hsp70 lev... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5393297

实验名称：Inhibition of HSP90 in mouse EO771 cells assessed as change in ILK level at 7.5 uM in... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5393296

实验名称：Inhibition of HSP90 in mouse EO771 cells assessed as change in CDK4 level at 7.5 uM i... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5393295

实验名称：Induction of heat shock response in human Hs-578T cells assessed as change in Hsp70 l... 来源：ChEMBL 靶标：Hs-578T External Id：CHEMBL5393292

实验名称：Induction of heat shock response in human Hs-578T cells assessed as change in Hsp40 l... 来源：ChEMBL 靶标：Hs-578T External Id：CHEMBL5393291

实验名称：Inhibition of HSP90 in human Hs-578T cells assessed as degradation of CDK4 at 5 uM in... 来源：ChEMBL 靶标：Heat shock protein HSP 90-alpha External Id：CHEMBL5393290

实验名称：Antiproliferative activity against human Hs-578T cells assessed as reduction in cell ... 来源：ChEMBL 靶标：Hs-578T External Id：CHEMBL5393289

实验名称：Inhibition of HSP90 in mouse 4T1 cells assessed as reduction in CDK4 level at 7.5 uM ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5393288

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Enniatin A英文别名

• ENNIATIN A (LATERITIN I)
• ENNIATIN A
• Enniatin-A