BPR1R024

• 常用名: BPR1R024
• 英文名: BPR1R024
• CAS号: 2503015-75-4
• 分子量: 482.46
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₄H₂₁F₃N₆O₂
• 熔点: N/A
• 闪点: N/A

BPR1R024用途

BPR1R024是一种口服活性和选择性CSF1R抑制剂(IC50=0.53 nM)。

BPR1R024名称

• 英文名: BPR1R024

BPR1R024生物活性

• 描述: BPR1R024是一种口服活性和选择性CSF1R抑制剂(IC50=0.53 nM)。
• 相关类别:
  研究领域 >> 癌症
  研究领域 >> 炎症/免疫
  信号通路 >> 蛋白酪氨酸激酶 >> c-FMS
• 参考文献:

  [1]. Lee KH, et al. Discovery of BPR1R024, an Orally Active and Selective CSF1R Inhibitor that Exhibits Antitumor and Immunomodulatory Activity in a Murine Colon Tumor Model. J Med Chem. 2021 Oct 14;64(19):14477-14497.

BPR1R024物理化学性质

• 分子式: C₂₄H₂₁F₃N₆O₂
• 分子量: 482.46
• 储存条件: 2-8°C，密封，干燥

BPR1R024靶点实验

查看更多实验

实验名称：Inhibition of recombinant GST-AURKA (residues Ser123 to Ser401) (unknown origin) expr... 来源：ChEMBL 靶标：Aurora kinase A External Id：CHEMBL4845011

实验名称：Inhibition of human recombinant full length GST-AURKB using tetra(-LRRASLG) peptide a... 来源：ChEMBL 靶标：Aurora kinase B External Id：CHEMBL4845010

实验名称：Inhibition of recombinant GST-AURKA (residues Ser123 to Ser401) (unknown origin) expr... 来源：ChEMBL 靶标：Aurora kinase A External Id：CHEMBL4845009

实验名称：Inhibition of human recombinant GST-CSF1R (residues L534 to C972) expressed in Sf9 in... 来源：ChEMBL 靶标：Macrophage colony-stimulating factor 1 receptor External Id：CHEMBL4845008

实验名称：Half life in Sprague-Dawley rat at 5 mg/kg, iv measured up to 24 hrs by LC-MS/MS anal... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4845015

实验名称：Antiproliferative activity against mouse NFS-60 cells transfected with human ETV6-CSF... 来源：ChEMBL 靶标：NFS-60 External Id：CHEMBL4845014

实验名称：Antiproliferative activity against mouse BaF3 cells transfected with human ETV6-CSF1R... 来源：ChEMBL 靶标：BaF3 External Id：CHEMBL4845013

实验名称：Inhibition of human recombinant full length GST-AURKB using tetra(-LRRASLG) peptide a... 来源：ChEMBL 靶标：Aurora kinase B External Id：CHEMBL4845012

实验名称：Anti-inflammatory activity mouse RAW264.7 cells assessed as inhibition of LPS-induced... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL4845043

实验名称：Inhibition of CSF1R phosphorylation in human THP-1 cells by Western blotting analysis 来源：ChEMBL 靶标：Macrophage colony-stimulating factor 1 receptor External Id：CHEMBL4845042

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