Anticancer agent 63

• 常用名: Anticancer agent 63
• 英文名: Anticancer agent 63
• CAS号: 2529657-32-5
• 分子量: 394.33
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₇H₂₄F₃NOSe
• 熔点: N/A
• 闪点: N/A

Anticancer agent 63用途

抗癌剂63(化合物3h)可有效降低不同癌细胞系的活性,包括SW480、HeLa、A549和MCF-7,24小时的IC50值分别为4.9、11.5、9.4和3.4μM。抗癌药物63通过下调Bcl-2的表达,上调IL-2和Caspase-3的表达,诱导MCF-7细胞凋亡。抗癌剂63也显示出抗氧化活性。

Anticancer agent 63名称

• 英文名: Anticancer agent 63

Anticancer agent 63生物活性

• 描述: 抗癌剂63(化合物3h)可有效降低不同癌细胞系的活性,包括SW480、HeLa、A549和MCF-7,24小时的IC50值分别为4.9、11.5、9.4和3.4μM。抗癌药物63通过下调Bcl-2的表达,上调IL-2和Caspase-3的表达,诱导MCF-7细胞凋亡。抗癌剂63也显示出抗氧化活性。
• 相关类别:
  信号通路 >> 细胞凋亡 >> Bcl-2家族
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  信号通路 >> 细胞凋亡 >> 胱天蛋白酶
• 靶点实验:

  Caspase-3

  Bcl-2

• 参考文献:

  [1]. He X, et al. Synthesis and biological evaluation of organoselenium (NSAIDs-SeCN and SeCF3) derivatives as potential anticancer agents. Eur J Med Chem. 2020 Dec 15;208:112864.

Anticancer agent 63物理化学性质

• 分子式: C₁₇H₂₄F₃NOSe
• 分子量: 394.33

Anticancer agent 63靶点实验

查看更多实验

实验名称：Cytotoxicity against human SW480 cells assessed as reduction in cell viability measur... 来源：ChEMBL 靶标：SW480 External Id：CHEMBL4775046

实验名称：Cytotoxicity against human SW480 cells assessed as reduction in cell viability measur... 来源：ChEMBL 靶标：SW480 External Id：CHEMBL4775047

实验名称：Antioxidant activity assessed as GPx-like activity by measuring oxidation of NADPH to... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4775044

实验名称：Cytotoxicity against human SW480 cells assessed as reduction in cell viability measur... 来源：ChEMBL 靶标：SW480 External Id：CHEMBL4775045

实验名称：Induction of apoptosis in human MCF7 cells assessed as up regulation of IL-2 expressi... 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL4775058

实验名称：Induction of apoptosis in human MCF7 cells assessed as up regulation of caspase-3 exp... 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL4775059

实验名称：Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measure... 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL4775056

实验名称：Induction of apoptosis in human MCF7 cells assessed as down regulation of Bcl-2 expre... 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL4775057

实验名称：Antioxidant activity assessed as bleomycin-Fe2+-induced DNA degradation by measuring ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4775062

实验名称：Antioxidant activity assessed as DPPH radical scavenging activity incubated for 30 mi... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4775060

共19条，当前第1页，共2页

1

2