千日菊酰胺

• 常用名: 千日菊酰胺
• 英文名: N-ISOBUTYL-2,6,8-DECATRIENAMIDE
• CAS号: 25394-57-4
• 分子量: 221.34
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₄H₂₃NO
• 熔点: N/A
• 闪点: N/A

千日菊酰胺用途

Spilanthol 是一种具有口服活性的镇痛、神经保护、抗氧化、抗诱变、抗癌、抗炎、抗菌和杀虫化合物。Spilanthol 可诱导 cAMP 来抑制尿浓缩负调节机制。Spilanthol 能够用于利尿剂研究。

千日菊酰胺名称

• 中文名: 千日菊酰胺
• 英文名: spilanthol
• 中文别名: 花菊素

千日菊酰胺生物活性

• 描述: Spilanthol 是一种具有口服活性的镇痛、神经保护、抗氧化、抗诱变、抗癌、抗炎、抗菌和杀虫化合物。Spilanthol 可诱导 cAMP 来抑制尿浓缩负调节机制。Spilanthol 能够用于利尿剂研究。
• 相关类别:
  研究领域 >> 癌症
  研究领域 >> 感染
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 靶点实验:

  Cyclic Adenosine monophosphate (cAMP)[5]

• 参考文献:

  [1]. Alan F, et al. Spilanthol: occurrence, extraction, chemistry and biological activities. Elsevier. 2016:128-133

  [2]. Déciga-Campos M, et al. Antinociceptive effect of Heliopsis longipes extract and affinin in mice. Planta Med. 2010 May;76(7):665-70.

  [3]. Huang WC, et al. Spilanthol Inhibits COX-2 and ICAM-1 Expression via Suppression of NF-κB and MAPK Signaling in Interleukin-1β-Stimulated Human Lung Epithelial Cells. Inflammation. 2018 Oct;41(5):1934-1944.

  [4]. de Freitas-Blanco VS, et al. Spilanthol, the Principal Alkylamide from Acmella oleracea, Attenuates 5-Fluorouracil-Induced Intestinal Mucositis in Mice. Planta Med. 2019 Feb;85(3):203-209.

  [5]. [5]Gerbino A, et al.. Spilanthol from Acmella Oleracea Lowers the Intracellular Levels of cAMP Impairing NKCC2 Phosphorylation and Water Channel AQP2 Membrane Expression in Mouse Kidney. PLoS One. 2016 May 23;11(5):e0156021.

千日菊酰胺物理化学性质

• 分子式: C₁₄H₂₃NO
• 分子量: 221.34
• 精确质量: 221.17800
• PSA: 29.10000
• LogP: 3.61820
• InChIKey: BXOCHUWSGYYSFW-HVWOQQCMSA-N
• SMILES: CC=CC=CCCC=CC(=O)NCC(C)C
• 蒸汽压: 4.02E-06mmHg at 25°C

千日菊酰胺靶点实验

查看更多实验

实验名称：Contact toxicity against adult Tetragonisca angustula assessed as mortality at contac... 来源：ChEMBL 靶标：Tetragonisca angustula External Id：CHEMBL3078891

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实验名称：Selectivity ratio of LD50 for adult Solenopsis saevissima to LD50 for second-instar l... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3078893

实验名称：Selectivity ratio of LD50 for adult Tetragonisca angustula to LD50 for second-instar ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3078894

实验名称：Ratio of permethrin LD50 to compound LD50 for second-instar larvae of Tuta absoluta a... 来源：ChEMBL 靶标：Tuta absoluta External Id：CHEMBL3078895

实验名称：Contact toxicity against adult Tetragonisca angustula assessed as mortality after 24 ... 来源：ChEMBL 靶标：Tetragonisca angustula External Id：CHEMBL3078896

实验名称：Contact toxicity against adult Solenopsis saevissima assessed as mortality after 24 h... 来源：ChEMBL 靶标：Solenopsis saevissima External Id：CHEMBL3078897

实验名称：Contact toxicity against second-instar larvae of Tuta absoluta assessed as mortality ... 来源：ChEMBL 靶标：Tuta absoluta External Id：CHEMBL3078898

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