mGAT3/4-IN-1

• 常用名: mGAT3/4-IN-1
• 英文名: mGAT3/4-IN-1
• CAS号: 2556833-57-7
• 分子量: 503.12
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₆H₃₁ClN₂O₂S₂
• 熔点: N/A
• 闪点: N/A

mGAT3/4-IN-1用途

mGAT3/4-IN-1(化合物19b)是一种有效的mGAT3/mGAT4抑制剂,pIC50值分别为5.31和5.24。在糖尿病神经病变小鼠中,mGAT3/4-IN-1表现出显著的触觉异常痛觉降低[1]。

mGAT3/4-IN-1名称

• 英文名: mGAT3/4-IN-1

mGAT3/4-IN-1生物活性

• 描述: mGAT3/4-IN-1(化合物19b)是一种有效的mGAT3/mGAT4抑制剂,pIC50值分别为5.31和5.24。在糖尿病神经病变小鼠中,mGAT3/4-IN-1表现出显著的触觉异常痛觉降低[1]。
• 相关类别:
  信号通路 >> 跨膜转运 >> GABA受体
  研究领域 >> 代谢疾病
  研究领域 >> 神经疾病
  信号通路 >> 神经信号通路 >> GABA受体
• 靶点实验:

  pIC50: 4.86 ± 0.10 (mGAT1), 4.98 ± 0.05 (mGAT2), 5.31 ± 0.04 (mGAT3), 5.24 ± 0.05 (mGAT4)[1]

• 参考文献:

  [1]. Zaręba P, et al. Novel mouse GABA uptake inhibitors with enhanced inhibitory activity toward mGAT3/4 and their effect on pain threshold in mice. Eur J Med Chem. 2020 Feb 15;188:111920.

mGAT3/4-IN-1物理化学性质

• 分子式: C₂₆H₃₁ClN₂O₂S₂
• 分子量: 503.12

mGAT3/4-IN-1靶点实验

查看更多实验

实验名称：Antiallodynic activity in oxaliplatin-induced diabetic neuropathy pain Albino Swiss m... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4767587

实验名称：Inhibition of mouse GAT3 expressed in HEK293 cell line assessed as inhibition of [3H]... 来源：ChEMBL 靶标：Sodium- and chloride-dependent GABA transporter 3 External Id：CHEMBL4767558

实验名称：Inhibition of mouse GAT2 expressed in HEK293 cell line assessed as inhibition of [3H]... 来源：ChEMBL 靶标：Sodium- and chloride-dependent GABA transporter 2 External Id：CHEMBL4767559

实验名称：Inhibition of mouse GAT4 expressed in HEK293 cell line assessed as inhibition of [3H]... 来源：ChEMBL 靶标：Sodium- and chloride-dependent GABA transporter 3 External Id：CHEMBL4767588

实验名称：Displacement of [3H]NO711 from mouse GAT1 expressed in HEK293 cells at 100 uM measure... 来源：ChEMBL 靶标：Sodium- and chloride-dependent GABA transporter 1 External Id：CHEMBL4767589

实验名称：Antihyperalgesic activity in oxaliplatin-induced diabetic acute neuropathy pain Albin... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4767570

实验名称：Antihyperalgesic activity in oxaliplatin-induced diabetic late neuropathy pain Albino... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4767571

实验名称：Antiallodynic activity in oxaliplatin-induced diabetic neuropathy pain Albino Swiss m... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4767568

实验名称：Antihyperalgesic activity in oxaliplatin-induced diabetic acute neuropathy pain Albin... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4767569

实验名称：Antihyperalgesic activity in oxaliplatin-induced diabetic late neuropathy pain Albino... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4767572

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