RIPK1-IN-16

• 常用名: RIPK1-IN-16
• 英文名: RIPK1-IN-16
• CAS号: 2561431-77-2
• 分子量: 393.46
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₁₉N₅O₂S
• 熔点: N/A
• 闪点: N/A

RIPK1-IN-16用途

RIPK1-IN-16 是一种有口服活性的RIPK1 的有效抑制剂。RIPK1-IN-16 在体内通过阻断 RIPK1 介导的坏死下垂抑制过度炎症。RIPK1-IN-16 保护小鼠免受 TNF 诱导的全身炎症反应综合征和败血症。

RIPK1-IN-16名称

• 英文名: RIPK1-IN-16

RIPK1-IN-16生物活性

• 描述: RIPK1-IN-16 是一种有口服活性的RIPK1 的有效抑制剂。RIPK1-IN-16 在体内通过阻断 RIPK1 介导的坏死下垂抑制过度炎症。RIPK1-IN-16 保护小鼠免受 TNF 诱导的全身炎症反应综合征和败血症。
• 相关类别:
  信号通路 >> 细胞凋亡 >> RIP激酶
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Ling ZY, et al. Protective Effect of a Novel RIPK1 Inhibitor, Compound 4-155, in Systemic Inflammatory Response Syndrome and Sepsis. Inflammation. 2023 Oct;46(5):1796-1809.

RIPK1-IN-16物理化学性质

• 分子式: C₂₀H₁₉N₅O₂S
• 分子量: 393.46

RIPK1-IN-16靶点实验

查看更多实验

实验名称：Anti-necroptotic activity in human HT-29 cells assessed as inhibition of hTNFalpha/Z-... 来源：ChEMBL 靶标：HT-29 External Id：CHEMBL4842515

实验名称：Inhibition of RIPK3 phosphorylation in Z-VAD-fmk (TSZ)-induced human HT-29 cells at 1... 来源：ChEMBL 靶标：Receptor-interacting serine/threonine-protein kinase 3 External Id：CHEMBL4842519

实验名称：Cytotoxicity against human HT-29 cells assessed as reduction in cell viability 来源：ChEMBL 靶标：HT-29 External Id：CHEMBL5147327

实验名称：Inhibition of RIPK1 phosphorylation in Z-VAD-fmk (TSZ)-induced human HT-29 cells at 1... 来源：ChEMBL 靶标：Receptor-interacting serine/threonine-protein kinase 1 External Id：CHEMBL4842518

实验名称：Binding affinity to wild-type human partial length RIPK1 (M1 to K305 residues) expres... 来源：ChEMBL 靶标：Receptor-interacting serine/threonine-protein kinase 1 External Id：CHEMBL5147328

实验名称：Anti-necroptotic activity in human HT-29 cells assessed as inhibition of Z-VAD-fmk (T... 来源：ChEMBL 靶标：HT-29 External Id：CHEMBL4842517

实验名称：Cytotoxicity against human HT-29 cells assessed as reduction in cell viability measur... 来源：ChEMBL 靶标：HT-29 External Id：CHEMBL4842516

实验名称：Anti-necroptosis activity against human HT-29 cells assessed as inhibition of TSZ-ind... 来源：ChEMBL 靶标：HT-29 External Id：CHEMBL5319714

实验名称：Cytotoxicity against human HT-29 cells assessed as reduction in cell viability measur... 来源：ChEMBL 靶标：HT-29 External Id：CHEMBL5319715

实验名称：Inhibition of MLKL phosphorylation in Z-VAD-fmk (TSZ)-induced human HT-29 cells measu... 来源：ChEMBL 靶标：Mixed lineage kinase domain-like protein External Id：CHEMBL4842523

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