KTX-955

更新时间：2026-07-01 10:07:25

KTX-955用途

KTX-955是一种有效的IRAK4降解剂,IRAK4和Ikaros的DC50值分别为5nM和130nM。KTX-955可用于抗癌研究[1][2]。

英文名	KTX-955

描述	KTX-955是一种有效的IRAK4降解剂,IRAK4和Ikaros的DC50值分别为5nM和130nM。KTX-955可用于抗癌研究[1][2]。
相关类别	研究领域 >> 癌症信号通路 >> 免疫及炎症 >> IRAK 信号通路 >> 蛋白酪氨酸激酶 >> IRAK
靶点实验	IRAK4:5 nM (IC50)
体外研究	KTX-955(化合物I-312)在OCI-LY10中24小时降解IRAK4,IC50＜0.05μM[1]。
参考文献	[1]. Matthew Weiss. Discovery and characterization of IRAKIMiDs: degraders targeting both IRAK4 and IMiD substrates for oncology indications. Northeastern Section, ACS (NESACS). [2]. Nello Mainolfi, et al. Irak degraders and uses thereof. WO2020264499A1

分子式	C₄₆H₅₁F₃N₈O₇
分子量	884.94

实验名称：Plasma protein binding in Sprague-Dawley rat at 1 uM by UPLC-MS/MS analysis
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5525813

实验名称：Oral bioavailability in rat at 10 mg/kg by LC-MS/MS analysis
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5525810

实验名称：AUC in rat at 10 mg/kg, po by LC-MS/MS analysis
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5525807

实验名称：Half life in rat at 2 mg/kg, iv by LC-MS/MS analysis
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5525806

实验名称：Volume of distribution at steady state in rat at 2 mg/kg, iv by LC-MS/MS analysis
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5525805

实验名称：Clearance in rat at 2 mg/kg, iv by LC-MS/MS analysis
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5525804

实验名称：Metabolic stability in rat liver microsomes assessed as intrinsic clearance at 1 uM m...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5525802

实验名称：Metabolic stability in human liver microsomes assessed as intrinsic clearance at 1 uM...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5525801

实验名称：Passive permeability of the compound in wild type MDCK cells across apical to basolat...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL5525800

实验名称：Antiproliferative activity against human OCI-Ly10 cells measured after 4 days by Cell...
来源：ChEMBL
靶标：OCI-Ly10
External Id：CHEMBL5525799

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