Cbl-b-IN-3

• 常用名: Cbl-b-IN-3
• 英文名: Cbl-b-IN-3
• CAS号: 2573775-59-2
• 分子量: 537.62
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₀H₃₄F₃N₅O
• 熔点: N/A
• 闪点: N/A

Cbl-b-IN-3用途

Cbl-b-IN-3(化合物23)是一种casitas b系淋巴瘤原癌基因-b(Cbl-b)抑制剂,IC50＜1nM。Cbl-b是一种负调节T细胞活化的E3泛素连接酶[1]。

Cbl-b-IN-3名称

• 英文名: Cbl-b-IN-3

Cbl-b-IN-3生物活性

• 描述: Cbl-b-IN-3(化合物23)是一种casitas b系淋巴瘤原癌基因-b(Cbl-b)抑制剂,IC50＜1nM。Cbl-b是一种负调节T细胞活化的E3泛素连接酶[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 代谢酶/蛋白酶 >> E1/E2/E3酶
• 靶点实验:

  IC50: < 1 nM (Cbl-b)[1]

• 体外研究: Cbl-b-IN-3(化合物23)增强由单独或与抗CD28抗体组合的抗CD3抗体刺激的T细胞的IL-2分泌[1]。
• 参考文献:

  [1]. Arthur T. Sands, et al. Substituted benzyl-triazole compounds for cbl-b inhibition, and further uses thereof. WO2020264398A1.

Cbl-b-IN-3物理化学性质

• 分子式: C₃₀H₃₄F₃N₅O
• 分子量: 537.62
• InChIKey: HUOLMBXGHHSYHC-QORSJFMISA-N
• SMILES: CC1CCCN(Cc2cc3c(c(C(F)(F)F)c2)CN(c2cccc(C4(c5nncn5C)CC(C)C4)c2)C3=O)C1

Cbl-b-IN-3靶点实验

查看更多实验

实验名称：Displacement of FAM-labeled probe from recombinant biotinylated Cbl-b (unknown origin... 来源：ChEMBL 靶标：E3 ubiquitin-protein ligase CBL-B External Id：CHEMBL5393375

实验名称：Inhibition of Cbl-b (unknown origin) by TR-FRET assay 来源：ChEMBL 靶标：E3 ubiquitin-protein ligase CBL-B External Id：CHEMBL5579259

实验名称：Lipophilicity, logD of compound in octanol/aqueous buffer at pH 7.4 incubated for 2 h... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5579260

实验名称：Intrinsic clearance in human liver microsome at 1 uM incubated for 30 mins in presenc... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5579261

实验名称：Inhibition of CBL-B (unknown origin) 来源：ChEMBL 靶标：E3 ubiquitin-protein ligase CBL-B External Id：CHEMBL5586105

实验名称：Inhibition of C-CBL (unknown origin) 来源：ChEMBL 靶标：N/A External Id：CHEMBL5586106

实验名称：Selectivity ratio of IC50 for CBL-B (unknown origin) to IC50 for c-CBL (unknown origi... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5586107

共7条，当前第1页，共1页

1