PD173955

• 常用名: PD173955
• 英文名: PD173955
• CAS号: 260415-63-2
• 分子量: 443.349
• 密度: 1.5±0.1 g/cm3
• 沸点: 626.7±65.0 °C at 760 mmHg
• 分子式: C₂₁H₁₆Cl₂N₄OS
• 熔点: N/A
• 闪点: 332.8±34.3 °C

PD173955用途

PD173955是Src激酶家族选择性抑制剂,对Src、Yes和Abl激酶IC50值约为22nM,对FGFR_alpha_抑制性弱,对InsR和PKC无活性。

PD173955名称

• 中文名: 6-(2,6-二氯苯基)-8-甲基-2-[[3-(甲硫基)苯基]氨基]吡啶并[2,3-d]嘧啶-7(8H)-酮
• 英文名: 6-(2,6-dichlorophenyl)-8-methyl-2-(3-methylsulfanylanilino)pyrido[2,3-d]pyrimidin-7-one

PD173955生物活性

• 描述: PD173955是Src激酶家族选择性抑制剂,对Src、Yes和Abl激酶IC50值约为22nM,对FGFR_alpha_抑制性弱,对InsR和PKC无活性。
• 相关类别:
  信号通路 >> 蛋白酪氨酸激酶 >> BCR-ABL
  信号通路 >> 蛋白酪氨酸激酶 >> SRC
  研究领域 >> 癌症
• 参考文献:

  [1]. Moasser MM, et al. Inhibition of Src kinases by a selective tyrosine kinase inhibitor causes mitotic arrest. Cancer Res. 1999 Dec 15;59(24):6145-52.

  [2]. Kraus GA, et al. New effective inhibitors of the Abelson kinase. Bioorg Med Chem. 2010 Sep 1;18(17):6316-21.

  [3]. Windham TC, et al. Src activation regulates anoikis in human colon tumor cell lines. Oncogene. 2002 Nov 7;21(51):7797-807.

PD173955物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 626.7±65.0 °C at 760 mmHg
• 分子式: C₂₁H₁₆Cl₂N₄OS
• 分子量: 443.349
• 闪点: 332.8±34.3 °C
• 精确质量: 442.042175
• PSA: 88.34000
• LogP: 4.74
• InChIKey: VAARYSWULJUGST-UHFFFAOYSA-N
• SMILES: CSc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1
• 外观性状: 类白色至黄色固体
• 蒸汽压: 0.0±1.8 mmHg at 25°C
• 折射率: 1.725
• 储存条件: -20℃

PD173955靶点实验

查看更多实验

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-keats_OPM1-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-OC1MY5-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-KMS_34-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-keats_L363-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-keats_OCIMY7-m4-1

实验名称：Inhibition of N-terminal GST-tagged recombinant human MKK3 S198E/T193E mutant express... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5550262

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-MM1R-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-mm1s-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-KMS-28PE-m4-1

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PD173955英文别名

• 6-(2,6-Dichlorophenyl)-8-methyl-2-{[3-(methylsulfanyl)phenyl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one
• 6-(2,6-dichlorophenyl)-8-methyl-2-{[3-(methylthio)phenyl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one
• 6-(2,6-DICHLORO-PHENYL)-8-METHYL-2-(3-METHYLSULFANYL-PHENYLAMINO)-8H-PYRIDO[2,3-D]PYRIMIDIN-7-ONE
• PD173955