Enfumafungin

• 常用名: Enfumafungin
• 英文名: Enfumafungin
• CAS号: 260979-95-1
• 分子量: 708.88
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₈H₆₀O₁₂
• 熔点: N/A
• 闪点: N/A

Enfumafungin用途

Enfumafungin,一种三萜糖苷,是从 Hormonema 内生物种的提取物中分离得到的。Enfumafungin 是一种抗真菌化合物,可作为 (1,3)-beta-D-葡聚糖合酶抑制剂作用在真菌细胞壁上。Enfumafungin 对酵母和真菌(隐球菌除外)具有特异性,不抑制枯草芽孢杆菌的生长。

Enfumafungin名称

• 英文名: Enfumafungin

Enfumafungin生物活性

• 描述: Enfumafungin,一种三萜糖苷,是从 Hormonema 内生物种的提取物中分离得到的。Enfumafungin 是一种抗真菌化合物,可作为 (1,3)-beta-D-葡聚糖合酶抑制剂作用在真菌细胞壁上。Enfumafungin 对酵母和真菌(隐球菌除外)具有特异性,不抑制枯草芽孢杆菌的生长。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 真菌
• 靶点实验:

  (1,3)-beta-D-glucan synthase[1]

• 体外研究: Enfumafungin(24-48小时)的MIC小于0.5μg/mL抗念珠菌和曲霉菌,对隐球菌无效,包括脱囊形式(MY2062)[1]。
• 体内研究: 恩复马芬净(50-200mg/kg；i、 每天两次,连续两天)使c.f.u.在c。白色念珠菌,ED90为90 mg/kg[1]。
• 参考文献:

  [1]. Peláez F, et, al. The discovery of enfumafungin, a novel antifungal compound produced by an endophytic Hormonema species biological activity and taxonomy of the producing organisms. Syst Appl Microbiol. 2000 Oct;23(3):333-43.

  [2]. Onishi J, et, al. Discovery of novel antifungal (1,3)-beta-D-glucan synthase inhibitors. Antimicrob Agents Chemother. 2000 Feb;44(2):368-77.

Enfumafungin物理化学性质

• 分子式: C₃₈H₆₀O₁₂
• 分子量: 708.88
• InChIKey: IAOFPTKYKOAKGZ-CRWQHXLTSA-N
• SMILES: CC(=O)OC1CC23C4=CCC5(C)C(C(=O)O)C(C)(C(C)C(C)C)CCC5(C)C4CCC2C(C)(COC3O)C1OC1OC(CO)C(O)C(O)C1O
• 储存条件: 2-8°C，干燥，密封

Enfumafungin安全信息

• 危害码 (欧洲): Xi

Enfumafungin靶点实验

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