RORγt/DHODH-IN-2

• 常用名: RORγt/DHODH-IN-2
• 英文名: RORγt/DHODH-IN-2
• CAS号: 2641758-86-1
• 分子量: 434.60
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₅H₃₀N₄OS
• 熔点: N/A
• 闪点: N/A

RORγt/DHODH-IN-2用途

RORγt/DHODH-IN-2(化合物1)是一种有效的双RORγt/DHODH抑制剂。RORγt/DHODH-IN-2可用于炎症性肠病(IBD)研究[1]。

RORγt/DHODH-IN-2名称

• 英文名: RORγt/DHODH-IN-2

RORγt/DHODH-IN-2生物活性

• 描述: RORγt/DHODH-IN-2(化合物1)是一种有效的双RORγt/DHODH抑制剂。RORγt/DHODH-IN-2可用于炎症性肠病(IBD)研究[1]。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> ROR
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Ji-An Chen, et al. Discovery of Orally Available Retinoic Acid Receptor-Related Orphan Receptor γ-t/Dihydroorotate Dehydrogenase Dual Inhibitors for the Treatment of Refractory Inflammatory Bowel Disease. J Med Chem. 2022 Jan 13;65(1):592-615.

RORγt/DHODH-IN-2物理化学性质

• 分子式: C₂₅H₃₀N₄OS
• 分子量: 434.60

RORγt/DHODH-IN-2靶点实验

查看更多实验

实验名称：Metabolic stability in mouse liver microsomes assessed as half life at 1 mM preincuba... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5044071

实验名称：Inhibition of human GAL4-fused RORgammat LBD transfected in HEK293T cell measured aft... 来源：ChEMBL 靶标：Nuclear receptor ROR-gamma External Id：CHEMBL5044066

实验名称：Inhibition of human GAL4-fused RORgammat LBD transfected in HEK293T cell at 10 uM mea... 来源：ChEMBL 靶标：Nuclear receptor ROR-gamma External Id：CHEMBL5044065

实验名称：Inhibition of human GAL4-fused RORgammat LBD transfected in HEK293T cell at 1 uM meas... 来源：ChEMBL 靶标：Nuclear receptor ROR-gamma External Id：CHEMBL5044064

实验名称：Metabolic stability in mouse liver microsomes assessed as intrinsic clearance at 1 mM... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5044070

实验名称：Inhibition of human recombinant DHODH expressed in Escherichia coli BL21 (DE3) using ... 来源：ChEMBL 靶标：Dihydroorotate dehydrogenase (quinone), mitochondrial External Id：CHEMBL5044068

实验名称：Inhibition of human recombinant DHODH expressed in Escherichia coli BL21 (DE3) using ... 来源：ChEMBL 靶标：Dihydroorotate dehydrogenase (quinone), mitochondrial External Id：CHEMBL5044067

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