MRS1754

• 常用名: MRS1754
• 英文名: MRS 1754
• CAS号: 264622-58-4
• 分子量: 486.52200
• 密度: 1.38g/cm3
• 沸点: N/A
• 分子式: C₂₆H₂₆N₆O₄
• 熔点: N/A
• 闪点: N/A

MRS1754用途

MRS 1754 是一种选择性 A2B 腺苷受体拮抗剂,对人和大鼠的 A1 和 A3 受体具有非常低的亲和力。

MRS1754名称

• 中文名: MRS1754
• 英文名: N-(4-cyanophenyl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide

MRS1754生物活性

• 描述: MRS 1754 是一种选择性 A2B 腺苷受体拮抗剂,对人和大鼠的 A1 和 A3 受体具有非常低的亲和力。
• 相关类别:
  研究领域 >> 炎症/免疫
  研究领域 >> 代谢疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 腺苷受体
• 靶点实验:

  A2B Adenosine Receptor[1]

• 体外研究: [3H] MRS 1754结合的最有效置换剂是MRS 1754.在HEK-293细胞膜中表达的[3H] MRS 1754与人A2B受体结合的Ki值为1.45±0.21nM [1]。
• 参考文献:

  [1]. Ji X, et al. [³H]MRS 1754, a selective antagonist radioligand for A(2B) adenosine receptors. Biochem Pharmacol. 2001 Mar 15;61(6):657-63.

MRS1754物理化学性质

• 密度: 1.38g/cm3
• 分子式: C₂₆H₂₆N₆O₄
• 分子量: 486.52200
• 精确质量: 486.20200
• PSA: 134.80000
• LogP: 3.33548
• InChIKey: AJBBEYXFRYFVNM-UHFFFAOYSA-N
• SMILES: CCCn1c(=O)c2[nH]c(-c3ccc(OCC(=O)Nc4ccc(C#N)cc4)cc3)nc2n(CCC)c1=O
• 储存条件: 2-8℃

MRS1754安全信息

• 安全声明 (欧洲): 22-24/25

MRS1754靶点实验

查看更多实验

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：Thermal Shift Assay. Domain: start/stop: M1-L298 来源：ChEMBL 靶标：Cyclin-dependent kinase 2 External Id：CHEMBL5062802

实验名称：Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay 来源：ChEMBL 靶标：N/A External Id：CHEMBL1266185

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells ui... 来源：ChEMBL 靶标：Adenosine receptor A2b External Id：CHEMBL618339

实验名称：Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based Syste... 来源：Broad Institute 靶标：N/A External Id：7124-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Incucyte cell viability with HEK293T 来源：ChEMBL 靶标：HEK-293T External Id：CHEMBL5058565

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells 来源：ChEMBL 靶标：Adenosine receptor A2b External Id：CHEMBL870844

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens] External Id：SIAE_INH_FP_1536_1X%INH PRUN

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MRS1754英文别名

• MRS 1754 hydrate
• MRS 1754
• ML 9 hydrochloride
• Lopac-M-6316