HIF-2α-IN-9

更新时间：2026-04-04 21:05:15

HIF-2α-IN-9用途

HIF-2α-IN-9(化合物35r)是HIF-2。HIF-2α-IN-9抑制VEGF-A(IC50=305 nM),调节肿瘤细胞中的生长促进基因,重新激活巨噬细胞介导的肿瘤免疫[1]。

英文名	HIF-2α-IN-9

描述	HIF-2α-IN-9(化合物35r)是HIF-2。HIF-2α-IN-9抑制VEGF-A(IC50=305 nM),调节肿瘤细胞中的生长促进基因,重新激活巨噬细胞介导的肿瘤免疫[1]。
相关类别	研究领域 >> 癌症信号通路 >> 代谢酶/蛋白酶 >> HIF/HIF脯氨酰-羟化酶
靶点实验	HIF-2α[1]
参考文献	[1]. Buchstaller H P, et al. Discovery of Cycloalkyl [c] thiophenes as Novel Scaffolds for Hypoxia-Inducible Factor-2伪 Inhibitors[J]. Journal of Medicinal Chemistry, 2023..

分子式	C₁₂H₁₃F₅O₄S₂
分子量	380.35

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