Ryuvidine

• 常用名: Ryuvidine
• 英文名: Ryuvidine
• CAS号: 265312-55-8
• 分子量: 284.33300
• 密度: 1.416g/cm3
• 沸点: 463.8ºC at 760 mmHg
• 分子式: C₁₅H₁₂N₂O₂S
• 熔点: N/A
• 闪点: 234.3ºC

Ryuvidine用途

瑞夫定是含SET结构域的蛋白质8(SETD8)的有效抑制剂,IC50为0.5µM,并在体外抑制H4K20的单甲基化[1]。瑞夫定还以6.0μM的IC50抑制CDK4,并对一系列人类癌细胞具有细胞毒性[2]。

Ryuvidine名称

• 英文名: Ryuvidine,2-Methyl-5-[(4-methylphenyl)amino]-4,7-benzothiazoledione

Ryuvidine生物活性

• 描述: 瑞夫定是含SET结构域的蛋白质8(SETD8)的有效抑制剂,IC50为0.5µM,并在体外抑制H4K20的单甲基化[1]。瑞夫定还以6.0μM的IC50抑制CDK4,并对一系列人类癌细胞具有细胞毒性[2]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
  信号通路 >> 细胞周期/DNA损伤 >> CDK
• 靶点实验:

  CDK4:6.0 μM (IC50)

• 参考文献:

  [1]. Ryu CK, et al. 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents. Bioorg Med Chem Lett. 2000 Mar 6;10(5):461-4.

  [2]. Blum G, et al. Small-molecule inhibitors of SETD8 with cellular activity. ACS Chem Biol. 2014 Nov 21;9(11):2471-8.

Ryuvidine物理化学性质

• 密度: 1.416g/cm3
• 沸点: 463.8ºC at 760 mmHg
• 分子式: C₁₅H₁₂N₂O₂S
• 分子量: 284.33300
• 闪点: 234.3ºC
• 精确质量: 284.06200
• PSA: 87.30000
• LogP: 3.20790
• InChIKey: HFPLHASLIOXVGS-UHFFFAOYSA-N
• SMILES: Cc1ccc(NC2=CC(=O)c3sc(C)nc3C2=O)cc1
• 蒸汽压: 8.83E-09mmHg at 25°C
• 折射率: 1.707

Ryuvidine靶点实验

查看更多实验

实验名称：Tocris HTS for Inhibitors of Aerobactin Synthetase lucA 来源：23265 External Id：IucA Pilot Assay Tocris Library

实验名称：Delta TM value showing the stabilisation of CAMK2G produced by compound binding 来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase type II subunit gamma External Id：CHEMBL3430795

实验名称：Delta TM value showing the stabilisation of CAMK4 produced by compound binding 来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase type IV External Id：CHEMBL3430796

实验名称：Delta TM value showing the stabilisation of CAMK2B produced by compound binding 来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase type II subunit beta External Id：CHEMBL3430793

实验名称：Delta TM value showing the stabilisation of CAMK2D produced by compound binding 来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase type II subunit delta External Id：CHEMBL3430794

实验名称：Delta TM value showing the stabilisation of CDK6 produced by compound binding 来源：ChEMBL 靶标：Cyclin-dependent kinase 6 External Id：CHEMBL3430799

实验名称：Delta TM value showing the stabilisation of CDKL1 produced by compound binding 来源：ChEMBL 靶标：Cyclin-dependent kinase-like 1 External Id：CHEMBL3430800

实验名称：Delta TM value showing the stabilisation of CAMKK2 produced by compound binding 来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase kinase 2 External Id：CHEMBL3430797

实验名称：Delta TM value showing the stabilisation of CDK2 produced by compound binding 来源：ChEMBL 靶标：Cyclin-dependent kinase 2 External Id：CHEMBL3430798

实验名称：Delta TM value showing the stabilisation of CLK2 produced by compound binding 来源：ChEMBL 靶标：Dual specificity protein kinase CLK2 External Id：CHEMBL3430803

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Ryuvidine英文别名

• Ryuvidine