LRRK2-IN-10

• 常用名: LRRK2-IN-10
• 英文名: LRRK2-IN-10
• CAS号: 2704562-80-9
• 分子量: 341.37
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₁₅N₅O
• 熔点: N/A
• 闪点: N/A

LRRK2-IN-10用途

LRRK2-IN-10 (compound 34) 是一种有效的、突变选择性的、脑渗透性 G2019S-LRRK2 激酶抑制剂,对 G2019S-LRRK2 pS935 和 G2019S-LRRK2 pS1292 的 IC50 分别为 11 nM 和 5.2 nM。LRRK2-IN-10 具有用于帕金森病研究的潜力。

LRRK2-IN-10名称

• 英文名: LRRK2-IN-10

LRRK2-IN-10生物活性

• 描述: LRRK2-IN-10 (compound 34) 是一种有效的、突变选择性的、脑渗透性 G2019S-LRRK2 激酶抑制剂,对 G2019S-LRRK2 pS935 和 G2019S-LRRK2 pS1292 的 IC50 分别为 11 nM 和 5.2 nM。LRRK2-IN-10 具有用于帕金森病研究的潜力。
• 相关类别:
  信号通路 >> 自噬 >> LRRK2
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Albert W Garofalo, et al. Brain-penetrant cyanoindane and cyanotetralin inhibitors of G2019S-LRRK2 kinase activity.

LRRK2-IN-10物理化学性质

• 分子式: C₂₀H₁₅N₅O
• 分子量: 341.37

LRRK2-IN-10靶点实验

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实验名称：Inhibition of human COX2 using arachidonic acid and ADHP as substrate at 10 uM by spe... 来源：ChEMBL 靶标：Prostaglandin G/H synthase 2 External Id：CHEMBL5369123

实验名称：Displacement of [3H]Dofetilide from recombinant hERG assessed as inhibition at 10 uM ... 来源：ChEMBL 靶标：Voltage-gated inwardly rectifying potassium channel KCNH2 External Id：CHEMBL5369124

实验名称：Displacement of [3H]U-69593 from human KOP assessed as inhibition at 10 uM in by scin... 来源：ChEMBL 靶标：Kappa-type opioid receptor External Id：CHEMBL5369121

实验名称：Displacement of [3H]Prazosin from human alpha 1A adrenergic receptor assessed as inhi... 来源：ChEMBL 靶标：Alpha-1A adrenergic receptor External Id：CHEMBL5369122

实验名称：Displacement of [3H]dexamethasone from human GR receptor assessed as inhibition at 10... 来源：ChEMBL 靶标：Glucocorticoid receptor External Id：CHEMBL5369119

实验名称：Displacement of [3H]CGP-12177 from human recombinant beta 2 adrenergic receptor asses... 来源：ChEMBL 靶标：Beta-2 adrenergic receptor External Id：CHEMBL5369120

实验名称：Inhibition of human recombinant PDE4D2 using FAM-cAMP as substrate at 10 uM spectrofl... 来源：ChEMBL 靶标：3',5'-cyclic-AMP phosphodiesterase 4D External Id：CHEMBL5369117

实验名称：Displacement of radioligand human recombinant norepinephrine transporter assessed as ... 来源：ChEMBL 靶标：Sodium-dependent noradrenaline transporter External Id：CHEMBL5369118

实验名称：Inhibition of sodium channel site 2 (unknown origin) at 10 uM by antagonist radioliga... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5369115

实验名称：Inhibition of human recombinant PDE3A using FAM-cAMP as substrate at 10 uM by spectro... 来源：ChEMBL 靶标：cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A External Id：CHEMBL5369116

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