PROTAC IRAK3 degrade-1

• 常用名: PROTAC IRAK3 degrade-1
• 英文名: PROTAC IRAK3 degrade-1
• CAS号: 2712600-00-3
• 分子量: 878.07
• 密度: N/A
• 沸点: N/A
• 分子式: C₄₇H₆₃N₁₁O₆
• 熔点: N/A
• 闪点: N/A

PROTAC IRAK3 degrade-1用途

PROTAC IRAK3 degrade-1是一种有效且选择性的IRAK3降解剂(IC50=5 nM)。

PROTAC IRAK3 degrade-1名称

• 英文名: PROTAC IRAK3 degrade-1

PROTAC IRAK3 degrade-1生物活性

• 描述: PROTAC IRAK3 degrade-1是一种有效且选择性的IRAK3降解剂(IC50=5 nM)。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 蛋白裂解靶向嵌合体 >> PROTAC
• 参考文献:

  [1]. Degorce SL, et al. Discovery of Proteolysis-Targeting Chimera Molecules that Selectively Degrade the IRAK3 Pseudokinase. J Med Chem. 2020 Sep 24;63(18):10460-10473.

PROTAC IRAK3 degrade-1物理化学性质

• 分子式: C₄₇H₆₃N₁₁O₆
• 分子量: 878.07
• InChIKey: ZUODKONSNNHSAJ-UHFFFAOYSA-N
• SMILES: CC(C)c1ccn2ncnc(NC3CCC(N4CCN(C(=O)CCC(=O)N5CCC(CCN6CCN(c7ccc8c(c7)C(=O)N(C7CCC(=O)NC7=O)C8=O)CC6)CC5)CC4)CC3)c12

PROTAC IRAK3 degrade-1靶点实验

查看更多实验

实验名称：Selectivity ratio of Kd(app) for displacement of polymer supported probe 25 binding t... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4729473

实验名称：Selectivity ratio of Kd(app) for displacement of polymer supported probe 25 binding t... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4729474

实验名称：Selectivity ratio of Kd(app) for displacement of polymer supported probe 25 binding t... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4729471

实验名称：Selectivity ratio of Kd(app) for displacement of polymer supported probe 25 binding t... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4729472

实验名称：Protac activity at CRBN/DHCR24 in LPS-induced human THP1 cells assessed as induction ... 来源：ChEMBL 靶标：Protein cereblon External Id：CHEMBL4729477

实验名称：Protac activity at CRBN/IRAK1 in LPS-induced human THP1 cells assessed as induction o... 来源：ChEMBL 靶标：Protein cereblon External Id：CHEMBL4729478

实验名称：Selectivity ratio of Kd(app) for displacement of polymer supported probe 25 binding t... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4729475

实验名称：Protac activity at CRBN/IRAK3 in LPS-induced human THP1 cells assessed as induction o... 来源：ChEMBL 靶标：Interleukin-1 receptor-associated kinase 3 External Id：CHEMBL4729476

实验名称：Inhibition of CDK8/cyclin C (unknown origin) at 0.1 uM relative to control 来源：ChEMBL 靶标：Cyclin-C External Id：CHEMBL4729455

实验名称：Inhibition of NTRK3 (unknown origin) at 0.1 uM relative to control 来源：ChEMBL 靶标：NT-3 growth factor receptor External Id：CHEMBL4729461

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