WES-1

• 常用名: WES-1
• 英文名: WES-1
• CAS号: 2748673-86-9
• 分子量: 396.46
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₂₀N₄O₃S
• 熔点: N/A
• 闪点: N/A

WES-1用途

WES-1(化合物8g)是碳酸酐酶IX(Ki:55.9μM)的抑制剂。WES-1对癌症细胞具有广谱抗增殖活性,如白血病(K-562和MOLT-4)、非小细胞肺癌癌症(NCI–H460)、癌症结肠癌(HCT 116和HCT-15)和黑色素瘤(LOX IMVI)细胞系[1]。

WES-1名称

• 英文名: WES-1

WES-1生物活性

• 描述: WES-1(化合物8g)是碳酸酐酶IX(Ki:55.9μM)的抑制剂。WES-1对癌症细胞具有广谱抗增殖活性,如白血病(K-562和MOLT-4)、非小细胞肺癌癌症(NCI–H460)、癌症结肠癌(HCT 116和HCT-15)和黑色素瘤(LOX IMVI)细胞系[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 代谢酶/蛋白酶 >> 碳酸酐酶
• 参考文献:

  [1]. Eldehna WM, et al. Design and synthesis of 6-arylpyridine-tethered sulfonamides as novel selective inhibitors of carbonic anhydrase IX with promising antitumor features toward the human colorectal cancer. Eur J Med Chem. 2023 Oct 5;258:115538.

WES-1物理化学性质

• 分子式: C₂₀H₂₀N₄O₃S
• 分子量: 396.46

WES-1靶点实验

查看更多实验

实验名称：Growth inhibition of human NCI-H322M cells at 10 uM measured after 48 hrs by SRB meth... 来源：ChEMBL 靶标：NCI-H322M External Id：CHEMBL5625677

实验名称：Growth inhibition of human NCI-H460 cells at 10 uM measured after 48 hrs by SRB metho... 来源：ChEMBL 靶标：NCI-H460 External Id：CHEMBL5625678

实验名称：Growth inhibition of human NCI-H522 cells at 10 uM measured after 48 hrs by SRB metho... 来源：ChEMBL 靶标：NCI-H522 External Id：CHEMBL5625679

实验名称：Growth inhibition of human COLO 205 cells at 10 uM measured after 48 hrs by SRB metho... 来源：ChEMBL 靶标：COLO 205 External Id：CHEMBL5625680

实验名称：Growth inhibition of human HCC 2998 cells at 10 uM measured after 48 hrs by SRB metho... 来源：ChEMBL 靶标：HCC 2998 External Id：CHEMBL5625681

实验名称：Growth inhibition of human HCT-116 cells at 10 uM measured after 48 hrs by SRB method... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL5625682

实验名称：Growth inhibition of human HCT-15 cells at 10 uM measured after 48 hrs by SRB method ... 来源：ChEMBL 靶标：HCT-15 External Id：CHEMBL5625683

实验名称：Growth inhibition of human HT-29 cells at 10 uM measured after 48 hrs by SRB method r... 来源：ChEMBL 靶标：HT-29 External Id：CHEMBL5625684

实验名称：Growth inhibition of human KM12 cells at 10 uM measured after 48 hrs by SRB method re... 来源：ChEMBL 靶标：KM12 External Id：CHEMBL5625685

实验名称：Growth inhibition of human SW620 cells at 10 uM measured after 48 hrs by SRB method r... 来源：ChEMBL 靶标：SW-620 External Id：CHEMBL5625686

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