QH536

• 常用名: QH536
• 英文名: QH536
• CAS号: 2754254-07-2
• 分子量: 535.76
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₃H₄₉N₃O₃
• 熔点: N/A
• 闪点: N/A

QH536用途

QH536(化合物29)是一种有效的HMGCR降解剂,EC50为0.22μM。QH536在诱导细胞内胆固醇积聚方面没有副作用。QH536具有抗炎作用,可用于心血管疾病和非酒精性脂肪性肝炎的研究[1]。

QH536名称

• 英文名: QH536

QH536生物活性

• 描述: QH536(化合物29)是一种有效的HMGCR降解剂,EC50为0.22μM。QH536在诱导细胞内胆固醇积聚方面没有副作用。QH536具有抗炎作用,可用于心血管疾病和非酒精性脂肪性肝炎的研究[1]。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> 代谢酶/蛋白酶 >> HMG-CoA还原酶(HMGCR)
  研究领域 >> 炎症/免疫
  研究领域 >> 代谢疾病
• 靶点实验:

  IC50: 0.22 μM (HMGCR)[1]

• 参考文献:

  [1]. Li XZ, et al. Synthesis of heterocyclic ring-fused analogs of HMG499 as novel degraders of HMG-CoA reductase that lower cholesterol. Eur J Med Chem. 2022 Jun 5;236:114323.

QH536物理化学性质

• 分子式: C₃₃H₄₉N₃O₃
• 分子量: 535.76

QH536靶点实验

查看更多实验

实验名称：Downregulation of HMGCR expression in CHO-K1 cells assessed as fold change in HMGCR e... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5164061

实验名称：Downregulation of lovastatin-induced HMGCR expression in CHO-K1 cells assessed as fol... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5164060

实验名称：Induction of degradation of HMGCR in CHO-K1 cells at 1 to 10 uM incubated for 8 hrs i... 来源：ChEMBL 靶标：3-hydroxy-3-methylglutaryl-coenzyme A reductase External Id：CHEMBL5164063

实验名称：Downregulation of lovastatin-induced HMGCR expression in CHO-K1 cells incubated for 1... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5164062

实验名称：Toxicity in human SV589 cells assessed as cholesterol accumulation in lysosome at 10 ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5164056

实验名称：Downregulation of lovastatin-induced HMGCR expression in CHO-K1 cells assessed as fol... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5164059

实验名称：Downregulation of lovastatin-induced HMGCR expression in CHO-K1 cells assessed as fol... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5164058

实验名称：Downregulation of HMGCR expression in CHO-K1 cells assessed as fold change in HMGCR e... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5164053

实验名称：Induction of degradation of hamster HMGCR (TM1-8)-GFP (1 to 346 residues) transfected... 来源：ChEMBL 靶标：3-hydroxy-3-methylglutaryl-coenzyme A reductase External Id：CHEMBL5164055

实验名称：Downregulation of HMGCR expression in CHO-K1 cells assessed as fold change in HMGCR e... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5164054

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