QH536

Modify Date: 2024-01-15 22:43:26

QH536 Structure
QH536 structure
Common Name QH536
CAS Number 2754254-07-2 Molecular Weight 535.76
Density N/A Boiling Point N/A
Molecular Formula C33H49N3O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of QH536


QH536 (Compound 29) is a potent HMGCR degrader with an EC50 of 0.22 μM. QH536 has no side-effect of inducing cholesterol accumulation in cells. QH536 shows anti-inflammatory and can be used for cardiovascular disease and nonalcoholic steatohepatitis research[1].

 Names

Name QH536

 QH536 Biological Activity

Description QH536 (Compound 29) is a potent HMGCR degrader with an EC50 of 0.22 μM. QH536 has no side-effect of inducing cholesterol accumulation in cells. QH536 shows anti-inflammatory and can be used for cardiovascular disease and nonalcoholic steatohepatitis research[1].
Related Catalog
Target

IC50: 0.22 μM (HMGCR)[1]

References

[1]. Li XZ, et al. Synthesis of heterocyclic ring-fused analogs of HMG499 as novel degraders of HMG-CoA reductase that lower cholesterol. Eur J Med Chem. 2022 Jun 5;236:114323.

 Chemical & Physical Properties

Molecular Formula C33H49N3O3
Molecular Weight 535.76
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