MK-1468

• 常用名: MK-1468
• 英文名: MK-1468
• CAS号: 2769107-89-1
• 分子量: 501.02
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₆H₃₃ClN₄O₄
• 熔点: N/A
• 闪点: N/A

MK-1468用途

MK-1468 是一种有高选择性的,脑渗透性的 LRRK2 抑制剂,其 IC50 为 0.8 nM。MK-1468 可以用于帕金森病的研究。

MK-1468名称

• 英文名: MK-1468

MK-1468生物活性

• 描述: MK-1468 是一种有高选择性的,脑渗透性的 LRRK2 抑制剂,其 IC50 为 0.8 nM。MK-1468 可以用于帕金森病的研究。
• 相关类别:
  信号通路 >> 自噬 >> LRRK2
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Kattar SD, et al. Discovery of MK-1468: A Potent, Kinome-Selective, Brain-Penetrant Amidoisoquinoline LRRK2 Inhibitor for the Potential Treatment of Parkinson's Disease. J Med Chem. 2023 Oct 20.

MK-1468物理化学性质

• 分子式: C₂₆H₃₃ClN₄O₄
• 分子量: 501.02

MK-1468靶点实验

查看更多实验

实验名称：Mutagenicity in Salmonella typhimurium TA100 at 30 to 5000 ug/plate incubated for 48 ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5374418

实验名称：Mutagenicity in Salmonella typhimurium TA1535 at 30 to 5000 ug/plate incubated for 48... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5374419

实验名称：Mutagenicity in Salmonella typhimurium TA1535 at 30 to 5000 ug/plate incubated for 48... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5374416

实验名称：Mutagenicity in Salmonella typhimurium TA98 at 30 to 5000 ug/plate incubated for 48 h... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5374417

实验名称：Protein binding in dog plasma incubated for 4 hrs by equilibrium dialysis method 来源：ChEMBL 靶标：N/A External Id：CHEMBL5374410

实验名称：Protein binding in rhesus monkey plasma incubated for 4 hrs by equilibrium dialysis m... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5374411

实验名称：Protein binding in human plasma incubated for 4 hrs by equilibrium dialysis method 来源：ChEMBL 靶标：N/A External Id：CHEMBL5374408

实验名称：Protein binding in rat plasma incubated for 4 hrs by equilibrium dialysis method 来源：ChEMBL 靶标：N/A External Id：CHEMBL5374409

实验名称：MRT in rhesus monkey at 3 mg/kg, iv measured after 24 hrs by LC-MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5374406

实验名称：Oral bioavailability in rhesus monkey at 10 mg/kg measured after 24 hrs by LC-MS/MS a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5374407

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