EGFR mutant-IN-2

• 常用名: EGFR mutant-IN-2
• 英文名: EGFR mutant-IN-2
• CAS号: 2770009-06-6
• 分子量: 556.60
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₇H₂₇F₃N₆O₂S
• 熔点: N/A
• 闪点: N/A

EGFR mutant-IN-2用途

EGFR突变体IN-2(化合物D51)是EGFR突变体抑制剂。EGFR突变体IN-2以14nM的IC50值抑制EGFRL858R/T790M/C797S突变体。EGFR突变体IN-2以62nM的IC50值抑制EGFRdel19/T790M/C797S突变体。EGFR突变体IN-2具有良好的PK参数、安全性、体内稳定性和抗肿瘤活性[1]。

EGFR mutant-IN-2名称

• 英文名: EGFR mutant-IN-2

EGFR mutant-IN-2生物活性

• 描述: EGFR突变体IN-2(化合物D51)是EGFR突变体抑制剂。EGFR突变体IN-2以14nM的IC50值抑制EGFRL858R/T790M/C797S突变体。EGFR突变体IN-2以62nM的IC50值抑制EGFRdel19/T790M/C797S突变体。EGFR突变体IN-2具有良好的PK参数、安全性、体内稳定性和抗肿瘤活性[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> JAK/STAT信号通路 >> EGFR
  信号通路 >> 蛋白酪氨酸激酶 >> EGFR
• 参考文献:

  [1]. Dong H, et al. Discovery of Potent and Wild-Type-Sparing Fourth-Generation EGFR Inhibitors for Treatment of Osimertinib-Resistance NSCLC. J Med Chem. 2023 May 25;66(10):6849-6868.

EGFR mutant-IN-2物理化学性质

• 分子式: C₂₇H₂₇F₃N₆O₂S
• 分子量: 556.60

EGFR mutant-IN-2靶点实验

查看更多实验

实验名称：Toxicity in BALB/c mouse xenografted with human NCI-H1975-TM cells harboring EGFR L85... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5341612

实验名称：Antitumor activity against human H1975-TM cells harboring EGFR L858R/T790M/C797S trip... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5341610

实验名称：Toxicity in BALB/c mouse xenografted with human NCI-H1975-TM cells harboring EGFR L85... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5341611

实验名称：Antitumor activity against human H1975-TM cells harboring EGFR L858R/T790M/C797S trip... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5341608

实验名称：Antitumor activity against human H1975-TM cells harboring EGFR L858R/T790M/C797S trip... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5341609

实验名称：Toxicity in ICR mouse assessed as effect on lung weight at 5000 mg/kg, po administere... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5341606

实验名称：Toxicity in ICR mouse assessed as effect on kidney weight at 5000 mg/kg, po administe... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5341607

实验名称：Toxicity in ICR mouse assessed as effect on liver weight at 5000 mg/kg, po administer... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5341604

实验名称：Toxicity in ICR mouse assessed as effect on spleen weight at 5000 mg/kg, po administe... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5341605

实验名称：Toxicity in ICR mouse assessed as effect on kidney weight at 1000 to 5000 mg/kg, po a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5341602

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