盐酸西曲酸酯

• 常用名: 盐酸西曲酸酯
• 英文名: Cetraxate HCl
• CAS号: 27724-96-5
• 分子量: 341.83000
• 密度: 1.182g/cm3
• 沸点: 480.9ºC at 760mmHg
• 分子式: C₁₇H₂₄ClNO₄
• 熔点: 238-240ºC
• 闪点: 244.6ºC

盐酸西曲酸酯用途

盐酸西曲沙汀(DV-1006),一种具有粘膜保护作用的口服活性抗溃疡剂,可用于胃溃疡研究[1]。盐酸西曲沙汀是一种有效的顶体蛋白酶顶体蛋白酶抑制剂,Ki和IC50分别为0.94μM和3.3μM[2]。

盐酸西曲酸酯名称

• 中文名: 盐酸西曲酸酯
• 英文名: Cetraxate, Hydrochloride

盐酸西曲酸酯生物活性

• 描述: 盐酸西曲沙汀(DV-1006),一种具有粘膜保护作用的口服活性抗溃疡剂,可用于胃溃疡研究[1]。盐酸西曲沙汀是一种有效的顶体蛋白酶顶体蛋白酶抑制剂,Ki和IC50分别为0.94μM和3.3μM[2]。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> Ser/Thr蛋白酶
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Fumihiko Katagiri, et al. Cetraxate raises levels of calcitonin gene-related peptide and substance P in human plasma. J Pharm Pharmacol. 2004 Apr;56(4):557-61.

  [2]. H Sumi, et al. Inhibitors of the acrosomal proteinase acrosin: human urinary trypsin inhibitor (UTI) and 4-(2-carboxyethyl) phenyl trans 4-aminomethylcyclohexanecarboxylate hydrochloride (DV-1006). Experientia. 1980 Sep 15;36(9):1103-4.

盐酸西曲酸酯物理化学性质

• 密度: 1.182g/cm3
• 沸点: 480.9ºC at 760mmHg
• 熔点: 238-240ºC
• 分子式: C₁₇H₂₄ClNO₄
• 分子量: 341.83000
• 闪点: 244.6ºC
• 精确质量: 341.13900
• PSA: 89.62000
• LogP: 3.87660
• InChIKey: USROQQUKEBHOFF-UHFFFAOYSA-N
• SMILES: Cl.NCC1CCC(C(=O)Oc2ccc(CCC(=O)O)cc2)CC1
• 折射率: 1.551
• 储存条件: 库房低温通风干燥

盐酸西曲酸酯毒性和生态

盐酸西曲酸酯靶点实验

查看更多实验

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实验名称：qHTS for Inhibitors of TGF-b 来源：NCGC 靶标：Smad3 [Homo sapiens] External Id：SMAD3101

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC External Id：APP-Toga-CHIKV-nsp2-p

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盐酸西曲酸酯英文别名

• 3-[4-[4-(aminomethyl)cyclohexanecarbonyl]oxyphenyl]propanoic acid,hydrochloride