Tubulin polymerization-IN-43

• 常用名: Tubulin polymerization-IN-43
• 英文名: Tubulin polymerization-IN-43
• CAS号: 2773345-90-5
• 分子量: 351.30
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₇H₁₃F₄N₃O
• 熔点: N/A
• 闪点: N/A

Tubulin polymerization-IN-43用途

Tubulin polymerization-IN-43 (compound 15h) 是一种微管蛋白聚合 (tubulin polymerization) 抑制剂。Tubulin polymerization-IN-43 通过靶向 Colchicine (HY-16569) 位点破坏细胞微管网络,促进白血病细胞的细胞周期停滞在 G2/M 期和细胞凋亡 (apoptosis),并抑制血管生成。

Tubulin polymerization-IN-43名称

• 英文名: Tubulin polymerization-IN-43

Tubulin polymerization-IN-43生物活性

• 描述: Tubulin polymerization-IN-43 (compound 15h) 是一种微管蛋白聚合 (tubulin polymerization) 抑制剂。Tubulin polymerization-IN-43 通过靶向 Colchicine (HY-16569) 位点破坏细胞微管网络,促进白血病细胞的细胞周期停滞在 G2/M 期和细胞凋亡 (apoptosis),并抑制血管生成。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> 微管/微管蛋白
  信号通路 >> 细胞骨架 >> 微管/微管蛋白
• 参考文献:

  [1]. Wu H, et, al. Discovery of novel N-aryl-2-trifluoromethyl-quinazoline-4-amine derivatives as the inhibitors of tubulin polymerization in leukemia cells. Eur J Med Chem. 2023 Aug 5;256:115470.

Tubulin polymerization-IN-43物理化学性质

• 分子式: C₁₇H₁₃F₄N₃O
• 分子量: 351.30
• InChIKey: YTTBMLZFUZWEBE-UHFFFAOYSA-N
• SMILES: COc1ccc(N(C)c2nc(C(F)(F)F)nc3ccc(F)cc23)cc1

Tubulin polymerization-IN-43靶点实验

查看更多实验

实验名称：Cytotoxicity against human K562 cells assessed as inhibition of cell growth incubated... 来源：ChEMBL 靶标：K562 External Id：CHEMBL5390387

实验名称：Cytotoxicity against human HeLa cells assessed as inhibition of cell growth incubated... 来源：ChEMBL 靶标：HeLa External Id：CHEMBL5390386

实验名称：Inhibition of microtubule polymerization in human K562 cells at 0.5 uM measured for 6... 来源：ChEMBL 靶标：Tubulin alpha-3C chain External Id：CHEMBL5390409

实验名称：Induction of microtubule depolymerization in human K562 cells at 500 nM incubated for... 来源：ChEMBL 靶标：Tubulin alpha-3C chain External Id：CHEMBL5390408

实验名称：Binding affinity to beta-tubulin colchicine binding site in human K562 cells assessed... 来源：ChEMBL 靶标：Tubulin beta 8B External Id：CHEMBL5390404

实验名称：Antiangiogenic activity against human HUVEC cells assessed as inhibition of cell migr... 来源：ChEMBL 靶标：HUVEC External Id：CHEMBL5390403

实验名称：Selectivity index, ratio of IC50 for cytotoxicity against human L02 cells to IC50 for... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5390402

实验名称：Selectivity index, ratio of IC50 for cytotoxicity against human L02 cells to IC50 for... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5390401

实验名称：Induction of cell cycle arrest in human HEL cells assessed as increase in accumulatio... 来源：ChEMBL 靶标：HEL External Id：CHEMBL5390399

实验名称：Induction of cell cycle arrest in human HEL cells assessed as reduction in accumulati... 来源：ChEMBL 靶标：HEL External Id：CHEMBL5390398

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