TLR7 agonist 14

• 常用名: TLR7 agonist 14
• 英文名: TLR7 agonist 14
• CAS号: 2832199-45-6
• 分子量: 516.63
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₉H₃₆N₆O₃
• 熔点: N/A
• 闪点: N/A

TLR7 agonist 14用途

TLR7 agonist 14 (compound 17b) 是一种高效 TLR7 激动剂,EC50 为 59 nM。TLR7 agonist 14 在低纳摩尔浓度下可有效诱导小鼠巨噬细胞和 hPBMC 的激活。

TLR7 agonist 14名称

• 英文名: TLR7 agonist 14

TLR7 agonist 14生物活性

• 描述: TLR7 agonist 14 (compound 17b) 是一种高效 TLR7 激动剂,EC50 为 59 nM。TLR7 agonist 14 在低纳摩尔浓度下可有效诱导小鼠巨噬细胞和 hPBMC 的激活。
• 相关类别:
  信号通路 >> 免疫及炎症 >> Toll样受体(TLR)
  研究领域 >> 炎症/免疫
• 靶点实验:

  TLR7:18 nM (IC50)

• 参考文献:

  [1]. Emma G DeYoung, et al. Synthesis and Optimization of 1-Substituted Imidazo[4,5- c]quinoline TLR7 Agonists. ACS Med Chem Lett. 2023 Sep 14;14(10):1358-1368.

TLR7 agonist 14物理化学性质

• 分子式: C₂₉H₃₆N₆O₃
• 分子量: 516.63
• InChIKey: QLONMNKKVKTOHQ-UHFFFAOYSA-N
• SMILES: CCCCc1nc2c(N)nc3ccccc3c2n1Cc1ccc(NC(=O)CCNC(=O)OC(C)(C)C)cc1

TLR7 agonist 14靶点实验

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实验名称：Potency index, ratio of resiquimod EC50 to test compound EC50 for agonist activity at... 来源：ChEMBL 靶标：Toll-like receptor 7 External Id：CHEMBL5370451

实验名称：Agonist activity at TLR8 in GM-CSF induced human MDM cells assessed as increase in TN... 来源：ChEMBL 靶标：Toll-like receptor 8 External Id：CHEMBL5370450

实验名称：Agonist activity at TLR7 in HEK-Blue hTLR7 cells assessed as increase in NFkappaB act... 来源：ChEMBL 靶标：Toll-like receptor 7 External Id：CHEMBL5370447

实验名称：Agonist activity at TLR7 in human PBMC cells assessed as increase in IFNalpha release... 来源：ChEMBL 靶标：Toll-like receptor 7 External Id：CHEMBL5370445

实验名称：Agonist activity at TLR8 in HEK-Blue hTLR8 cells assessed as increase in NFkappaB act... 来源：ChEMBL 靶标：Toll-like receptor 8 External Id：CHEMBL5370446

实验名称：Agonist activity at TLR7 in human PBMC cells assessed as increase in TNFalpha release... 来源：ChEMBL 靶标：Toll-like receptor 7 External Id：CHEMBL5370443

实验名称：Apparent permeability of the compound at 200 uM incubated for 5 hrs by PAMPA assay 来源：ChEMBL 靶标：N/A External Id：CHEMBL5370444

实验名称：Agonist activity at TLR7 in mouse RAW264.7 cells assessed as increase in NFkappaB act... 来源：ChEMBL 靶标：Toll-like receptor 7 External Id：CHEMBL5370442

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