Tubulin polymerization-IN-47

• 常用名: Tubulin polymerization-IN-47
• 英文名: Tubulin polymerization-IN-47
• CAS号: 2834087-62-4
• 分子量: 375.42
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₂₁N₃O₃
• 熔点: N/A
• 闪点: N/A

Tubulin polymerization-IN-47用途

Tubulinpolymerization-IN-47 (Compound 4h) 是一种 tubulin 聚合抑制剂和有丝分裂抑制剂。Tubulinpolymerization-IN-47 抑制神经母细胞瘤癌细胞增殖,对 Chp-134 和 Kelly 细胞系的IC50 分别为 7 和 12 nM。

Tubulin polymerization-IN-47名称

• 英文名: Tubulin polymerization-IN-47

Tubulin polymerization-IN-47生物活性

• 描述: Tubulinpolymerization-IN-47 (Compound 4h) 是一种 tubulin 聚合抑制剂和有丝分裂抑制剂。Tubulinpolymerization-IN-47 抑制神经母细胞瘤癌细胞增殖,对 Chp-134 和 Kelly 细胞系的IC50 分别为 7 和 12 nM。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> 微管/微管蛋白
  信号通路 >> 细胞骨架 >> 微管/微管蛋白
• 参考文献:

  [1]. Joshua Thammathong, et al. Fused Imidazopyrazine-Based Tubulin Polymerization Inhibitors Inhibit Neuroblastoma Cell Function. ACS Med. Chem. Lett. 2023.

Tubulin polymerization-IN-47物理化学性质

• 分子式: C₂₂H₂₁N₃O₃
• 分子量: 375.42
• InChIKey: SFOULTOXUOSZBX-UHFFFAOYSA-N
• SMILES: COc1cc(-c2nccn3cc(-c4ccc(C)cc4)nc23)cc(OC)c1OC

Tubulin polymerization-IN-47靶点实验

查看更多实验

实验名称：Induction of cell cycle arrest in human Kelly cells assessed as accumulation of cells... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5390931

实验名称：Inhibition of tubulin polymerization (unknown origin) assessed as destabilization of ... 来源：ChEMBL 靶标：Tubulin alpha-3C chain External Id：CHEMBL5390930

实验名称：Microsomal stability in human liver microsomes assessed as half life 来源：ChEMBL 靶标：N/A External Id：CHEMBL5390929

实验名称：Growth inhibition of MYCN-amplified human Kelly cells assessed as reduction in cell v... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5390928

实验名称：Growth inhibition of MYCN-amplified human CHP-134 cells assessed as reduction in cell... 来源：ChEMBL 靶标：CHP-134 External Id：CHEMBL5390927

实验名称：Antiproliferative activity against human A549 cells assessed as inhibition of cell gr... 来源：ChEMBL 靶标：A549 External Id：CHEMBL5153910

实验名称：Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of c... 来源：ChEMBL 靶标：MDA-MB-231 External Id：CHEMBL5153911

实验名称：Antiproliferative activity against human HepG2 cells assessed as inhibition of cell g... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL5153908

实验名称：Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL5153909

实验名称：Disruption of microtubule network in human Kelly cells at 100 nM incubated for 24 hrs... 来源：ChEMBL 靶标：Tubulin alpha-3C chain External Id：CHEMBL5390942

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