SIRT5 inhibitor 6

• 常用名: SIRT5 inhibitor 6
• 英文名: SIRT5 inhibitor 6
• CAS号: 2834736-82-0
• 分子量: 460.55
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₂₈N₆O₄S
• 熔点: N/A
• 闪点: N/A

SIRT5 inhibitor 6用途

SIRT5 Inhibitor 6 是一种有效的、具有底物竞争性和选择性的 SIRT5 抑制剂,IC50 为 3.0 μM。SIRT5 Inhibitor 6 具有治疗脓毒性 AKI 研究的潜力。

SIRT5 inhibitor 6名称

• 英文名: SIRT5 inhibitor 6

SIRT5 inhibitor 6生物活性

• 描述: SIRT5 Inhibitor 6 是一种有效的、具有底物竞争性和选择性的 SIRT5 抑制剂,IC50 为 3.0 μM。SIRT5 Inhibitor 6 具有治疗脓毒性 AKI 研究的潜力。
• 相关类别:
  信号通路 >> 表观遗传学 >> 抗衰老酶
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> 抗衰老酶
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Luohe Mou, et al, Structure-Activity Relationship Studies of 2,4,5-Trisubstituted Pyrimidine Derivatives Leading to the Identification of a Novel and Potent Sirtuin 5 Inhibitor against Sepsis-Associated Acute Kidney Injury. J Med Chem. 2023 Aug 24;66(16):11517-11535.

SIRT5 inhibitor 6物理化学性质

• 分子式: C₂₁H₂₈N₆O₄S
• 分子量: 460.55
• InChIKey: CEAPZJWXJWNRMC-UHFFFAOYSA-N
• SMILES: CCOC(=O)c1cnc(NCc2ccccc2)nc1NCCCNC(=S)NCCC(=O)O

SIRT5 inhibitor 6靶点实验

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实验名称：Stabilization of recombinant human SIRT5 (34 to 269 residues) assessed as melting tem... 来源：ChEMBL 靶标：NAD-dependent protein deacylase sirtuin-5, mitochondrial External Id：CHEMBL4830954

实验名称：Competitive inhibition of human recombinant SIRT5 (34 to 269 residues) assessed as in... 来源：ChEMBL 靶标：NAD-dependent protein deacylase sirtuin-5, mitochondrial External Id：CHEMBL4830953

实验名称：Inhibition of human SIRT5 来源：ChEMBL 靶标：NAD-dependent protein deacylase sirtuin-5, mitochondrial External Id：CHEMBL5361128

实验名称：Stabilization of recombinant human SIRT5 (34 to 269 residues) assessed as melting tem... 来源：ChEMBL 靶标：NAD-dependent protein deacylase sirtuin-5, mitochondrial External Id：CHEMBL4830955

实验名称：Inhibition of human SIRT5 (34 to 269 residues) using Ac-Leu-Gly-Ser-Lys (Su)-AMC as f... 来源：ChEMBL 靶标：NAD-dependent protein deacylase sirtuin-5, mitochondrial External Id：CHEMBL5364471

实验名称：Inhibition of human recombinant SIRT5 (34 to 269 residues) using Ac-Leu-Gly-Ser-Lys(S... 来源：ChEMBL 靶标：NAD-dependent protein deacylase sirtuin-5, mitochondrial External Id：CHEMBL4830944

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