罗伐他汀

• 常用名: 罗伐他汀
• 英文名: Rosuvastatin
• CAS号: 287714-41-4
• 分子量: 481.54
• 密度: 1.368 g/cm3
• 沸点: 745.6ºC at 760 mmHg
• 分子式: C₂₂H₂₈FN₃O₆S
• 熔点: N/A
• 闪点: 404.7ºC

罗伐他汀用途

Rosuvastatin是竞争性HMG-CoA还原酶抑制剂,IC50为11 nM。

罗伐他汀名称

• 中文名: 罗伐他汀
• 英文名: rosuvastatin
• 中文别名: 7-[4-(4-氟苯基)-6-异丙基-2-(甲基-甲磺酰-氨基)-嘧啶-5-基]-3,5-二羟基庚-6-烯酸 | 氘代罗苏伐他汀钠盐-d3 | 瑞舒伐他汀酸

罗伐他汀生物活性

• 描述: Rosuvastatin是竞争性HMG-CoA还原酶抑制剂,IC50为11 nM。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> HMG-CoA还原酶(HMGCR)
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Watanabe, M., et al., Synthesis and biological activity of methanesulfonamide pyrimidine- and N-methanesulfonyl pyrrole-substituted 3,5-dihydroxy-6-heptenoates, a novel series of HMG-CoA reductase inhibitors. Bioorg Med Chem, 1997. 5(2): p. 437-44.

  [2]. Schneck, D.W., et al., The effect of gemfibrozil on the pharmacokinetics of rosuvastatin. Clin Pharmacol Ther, 2004. 75(5): p. 455-63.

  [3]. Kim, Y.S., et al., Rosuvastatin suppresses the inflammatory responses through inhibition of c-Jun N-terminal kinase and Nuclear Factor-kappaB in endothelial cells. J Cardiovasc Pharmacol, 2007. 49(6): p. 376-83.

  [4]. Carswell, C.I., G.L. Plosker, and B. Jarvis, Rosuvastatin. Drugs, 2002. 62(14): p. 2075-85; discussion 2086-7.

  [5]. Stalker, T.J., A.M. Lefer, and R. Scalia, A new HMG-CoA reductase inhibitor, rosuvastatin, exerts anti-inflammatory effects on the microvascular endothelium: the role of mevalonic acid. Br J Pharmacol, 2001. 133(3): p. 406-12.

罗伐他汀物理化学性质

• 密度: 1.368 g/cm3
• 沸点: 745.6ºC at 760 mmHg
• 分子式: C₂₂H₂₈FN₃O₆S
• 分子量: 481.54
• 闪点: 404.7ºC
• PSA: 152.13000
• LogP: 2.14780
• InChIKey: BPRHUIZQVSMCRT-VEUZHWNKSA-N
• SMILES: CC(C)c1nc(N(C)S(C)(=O)=O)nc(-c2ccc(F)cc2)c1C=CC(O)CC(O)CC(=O)O
• 蒸汽压: 2.38E-23mmHg at 25°C
• 折射率: 1.597
• 储存条件: 2-8°C

罗伐他汀英文别名

• Reference source: Negwer
• volume-3 compound no
• ROSUVASTATIN-D3 SODIUM SALT
• 7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-(methyl-methylsulfonyl-amino)-pyrimidin-5-yl]-3,5-dihydroxy-hept-6-enoic acid
• 6-Heptenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl-d(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-, sodium salt, (3R,5S,6E)- (1:1)
• [3H]-Rosuvastatin
• Rosuvastatin
• Sodium (3R,5S,6E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[(H)methyl(methylsulfonyl)amino]-5-pyrimidinyl}-3,5-dihydroxy-6-heptenoate
• (3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-MethylMethanesulfonaMido)-6-(propan-2-yl)pyriMidin-5-yl]-3,5-dihydroxyhept-6-enoic acid
• MFCD08460959