RUNX-IN-2

• 常用名: RUNX-IN-2
• 英文名: RUNX-IN-2
• CAS号: 2893777-88-1
• 分子量: 1524.52
• 密度: N/A
• 沸点: N/A
• 分子式: C₇₁H₈₈Cl₂N₂₄O₁₁
• 熔点: N/A
• 闪点: N/A

RUNX-IN-2用途

RUNX-IN-2 (Compound Conjugate 3) 与 RUNX 结合序列共价结合,并抑制 RUNX 蛋白与其靶位点的结合。RUNX-IN-2 诱导 p53 依赖性的细胞凋亡 (apoptosis),并抑制细胞生长。RUNX-IN-2 抑制 PANC-1 异种移植小鼠的肿瘤生长。RUNX-IN-2 具有较高的烷基化效率和特异性。

RUNX-IN-2名称

• 英文名: RUNX-IN-2

RUNX-IN-2生物活性

• 描述: RUNX-IN-2 (Compound Conjugate 3) 与 RUNX 结合序列共价结合,并抑制 RUNX 蛋白与其靶位点的结合。RUNX-IN-2 诱导 p53 依赖性的细胞凋亡 (apoptosis),并抑制细胞生长。RUNX-IN-2 抑制 PANC-1 异种移植小鼠的肿瘤生长。RUNX-IN-2 具有较高的烷基化效率和特异性。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
• 靶点实验:

  RUNX[1]

• 参考文献:

  [1]. Hirose Y, et al. Anticancer Activities of DNA-Alkylating Pyrrole-Imidazole Polyamide Analogs Targeting RUNX Transcription Factors against p53-Mutated Pancreatic Cancer PANC-1 Cells. J Med Chem. 2023 Sep 14;66(17):12059-12068.

RUNX-IN-2物理化学性质

• 分子式: C₇₁H₈₈Cl₂N₂₄O₁₁
• 分子量: 1524.52

RUNX-IN-2靶点实验

查看更多实验

实验名称：Induction of apoptosis in human PANC-1 cells assessed as increase in phosphorylated p... 来源：ChEMBL 靶标：PANC-1 External Id：CHEMBL5366499

实验名称：Induction of apoptosis in human PANC-1 cells assessed as increase in phosphorylated p... 来源：ChEMBL 靶标：PANC-1 External Id：CHEMBL5366500

实验名称：Induction of apoptosis in human PANC-1 cells assessed as suppression of BCL11A mRNA l... 来源：ChEMBL 靶标：PANC-1 External Id：CHEMBL5366497

实验名称：Induction of apoptosis in human PANC-1 cells assessed as increase in phosphorylated p... 来源：ChEMBL 靶标：PANC-1 External Id：CHEMBL5366498

实验名称：Induction of apoptosis in human PANC-1 cells assessed as late apoptotic cells at 3 uM... 来源：ChEMBL 靶标：PANC-1 External Id：CHEMBL5366495

实验名称：Induction of apoptosis in human PANC-1 cells assessed as necrotic cells at 3 uM incub... 来源：ChEMBL 靶标：PANC-1 External Id：CHEMBL5366496

实验名称：Induction of apoptosis in human PANC-1 cells assessed as viable cells at 3 uM incubat... 来源：ChEMBL 靶标：PANC-1 External Id：CHEMBL5366493

实验名称：Induction of apoptosis in human PANC-1 cells assessed as early apoptotic cells at 3 u... 来源：ChEMBL 靶标：PANC-1 External Id：CHEMBL5366494

实验名称：Cytotoxicity against human PANC-1 cells assessed as cell viability at 3 uM incubated ... 来源：ChEMBL 靶标：PANC-1 External Id：CHEMBL5366491

实验名称：Cytotoxicity against human hTERT-HPNE cells assessed as cell viability at 3 uM incuba... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5366492

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