LSD1-IN-27

• 常用名: LSD1-IN-27
• 英文名: LSD1-IN-27
• CAS号: 2904571-94-2
• 分子量: 355.48
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₄H₂₅N₃
• 熔点: N/A
• 闪点: N/A

LSD1-IN-27用途

LSD1-IN-27 (Compound 5ac) 是一种 LSD1 抑制剂 (IC50: 13 nM)。LSD1-IN-27 抑制胃癌细胞的干细胞性和迁移。LSD1-IN-27 还可降低 BGC-823 和 MFC 细胞中 PD-L1 的表达。LSD1-IN-27 可增强对胃癌的 T 细胞免疫反应。

LSD1-IN-27名称

• 英文名: LSD1-IN-27

LSD1-IN-27生物活性

• 描述: LSD1-IN-27 (Compound 5ac) 是一种 LSD1 抑制剂 (IC50: 13 nM)。LSD1-IN-27 抑制胃癌细胞的干细胞性和迁移。LSD1-IN-27 还可降低 BGC-823 和 MFC 细胞中 PD-L1 的表达。LSD1-IN-27 可增强对胃癌的 T 细胞免疫反应。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 表观遗传学 >> 组蛋白去甲基化酶
  信号通路 >> 免疫及炎症 >> PD-1/PD-L1
• 靶点实验:

  13 nM (LSD1)[1]

• 参考文献:

  [1]. Dai XJ, et al. Novel acridine-based LSD1 inhibitors enhance immune response in gastric cancer. Eur J Med Chem. 2023 Nov 5;259:115684.

LSD1-IN-27物理化学性质

• 分子式: C₂₄H₂₅N₃
• 分子量: 355.48
• InChIKey: COFJGRODNLNWAE-UHFFFAOYSA-N
• SMILES: Cc1ccc2nc3c(C)c(C)ccc3c(Nc3ccc(N(C)C)cc3)c2c1

LSD1-IN-27靶点实验

查看更多实验

实验名称：Antitumor activity against MFC cells implanted in 615 mouse assessed as reduction in ... 来源：ChEMBL 靶标：MFC External Id：CHEMBL5627661

实验名称：Antiproliferative activity against MFC cells assessed as inhibition of cell prolifera... 来源：ChEMBL 靶标：MFC External Id：CHEMBL5627662

实验名称：Antitumor activity against MFC cells implanted in 615 mouse assessed as decrease in P... 来源：ChEMBL 靶标：MFC External Id：CHEMBL5627663

实验名称：Antitumor activity against MFC cells implanted in 615 mouse assessed as increase in I... 来源：ChEMBL 靶标：MFC External Id：CHEMBL5627664

实验名称：Antitumor activity against MFC cells implanted in 615 mouse assessed as increase in T... 来源：ChEMBL 靶标：MFC External Id：CHEMBL5627665

实验名称：Antitumor activity against MFC cells implanted in 615 mouse assessed as increase in I... 来源：ChEMBL 靶标：MFC External Id：CHEMBL5627666

实验名称：Inhibition of recombinant LSD1 (unknown origin) expressed in BL21(DE3) cells using H3... 来源：ChEMBL 靶标：Lysine-specific histone demethylase 1A External Id：CHEMBL5583228

实验名称：Binding affinity to LSD1 in human BGC-823 cells assessed as thermal stability at 2 uM... 来源：ChEMBL 靶标：Lysine-specific histone demethylase 1A External Id：CHEMBL5627637

实验名称：Inhibition of LSD1 in human BGC-823 cells assessed as induction of H3K4me1 accumulati... 来源：ChEMBL 靶标：Lysine-specific histone demethylase 1A External Id：CHEMBL5627638

实验名称：Inhibition of LSD1 in human BGC-823 cells assessed as induction of H3K4me2 accumulati... 来源：ChEMBL 靶标：Lysine-specific histone demethylase 1A External Id：CHEMBL5627639

共31条，当前第1页，共4页

1

2

3

4