hBChE-IN-2

• 常用名: hBChE-IN-2
• 英文名: hBChE-IN-2
• CAS号: 2923366-36-1
• 分子量: 464.60
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₇H₃₆N₄O₃
• 熔点: N/A
• 闪点: N/A

hBChE-IN-2用途

hBChE-IN-2(化合物15d)是丁酰胆碱酯酶(BChE)抑制剂(IC50为0.62μM)和大麻素受体2(CB2R)激动剂。hBChE-IN-2具有神经保护活性[1]。

hBChE-IN-2名称

• 英文名: hBChE-IN-2

hBChE-IN-2生物活性

• 描述: hBChE-IN-2(化合物15d)是丁酰胆碱酯酶(BChE)抑制剂(IC50为0.62μM)和大麻素受体2(CB2R)激动剂。hBChE-IN-2具有神经保护活性[1]。
• 相关类别:
  研究领域 >> 神经疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 大麻素受体
  信号通路 >> 神经信号通路 >> 疼痛
• 靶点实验:

  hBCHE:0.67 μM (IC50)

  hCB2-R:0.78 μM (IC50)

• 参考文献:

  [1]. Philipp Spatz, et al. Dual-Acting Small Molecules: Subtype-Selective Cannabinoid Receptor 2 Agonist/Butyrylcholinesterase Inhibitor Hybrids Show Neuroprotection in an Alzheimer's Disease Mouse Model. J Med Chem. 2023 May 11;66(9):6414-6435.

hBChE-IN-2物理化学性质

• 分子式: C₂₇H₃₆N₄O₃
• 分子量: 464.60

hBChE-IN-2靶点实验

查看更多实验

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实验名称：AUC (0 to infinity) in CD-1 mouse brain at 2 mg/kg, iv measured after 240 mins by LC-... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5341222

实验名称：Clearance in CD-1 mouse plasma at 2 mg/kg, iv measured after 240 mins by LC-MS/MS ana... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5341223

实验名称：AUC (0 to infinity) in CD-1 mouse plasma at 2 mg/kg, iv measured after 240 mins by LC... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5341221

实验名称：Half life in CD-1 mouse brain at 2 mg/kg, iv measured after 240 mins by LC-MS/MS anal... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5341218

实验名称：Tmax in CD-1 mouse brain at 2 mg/kg, iv measured after 240 mins by LC-MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5341216

实验名称：Half life in CD-1 mouse plasma at 2 mg/kg, iv measured after 240 mins by LC-MS/MS ana... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5341217

实验名称：Neuroprotective activity against amyloid beta (25 to 35) induced Alzheimer's disease ... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL5341210

实验名称：Neurotoxicity against mouse HT-22 cells assessed as cell viability at 0.75 to 25 uM t... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5341208

实验名称：Neuroprotective activity against amyloid beta (25 to 35) induced Alzheimer's disease ... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL5341209

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