MDM2/XIAP-IN-3

• 常用名: MDM2/XIAP-IN-3
• 英文名: MDM2/XIAP-IN-3
• CAS号: 2925583-17-9
• 分子量: 518.62
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₉H₃₀N₂O₅S
• 熔点: N/A
• 闪点: N/A

MDM2/XIAP-IN-3用途

MDM2/XIAP-IN-3(化合物3e)是一种双MDM2/XIAP抑制剂。MDM2/XIAP-IN-3降低MDM2和XIAP蛋白水平并增加p53表达,从而抑制癌症细胞生长并导致细胞死亡[1]。

MDM2/XIAP-IN-3名称

• 英文名: MDM2/XIAP-IN-3

MDM2/XIAP-IN-3生物活性

• 描述: MDM2/XIAP-IN-3(化合物3e)是一种双MDM2/XIAP抑制剂。MDM2/XIAP-IN-3降低MDM2和XIAP蛋白水平并增加p53表达,从而抑制癌症细胞生长并导致细胞死亡[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞凋亡 >> MDM-2/p53
  信号通路 >> 细胞凋亡 >> IAP
• 参考文献:

  [1]. Albadari N, et al. Synthesis and biological evaluation of dual MDM2/XIAP inhibitors based on the tetrahydroquinoline scaffold. Eur J Med Chem. 2023 Jul 5;255:115423.

MDM2/XIAP-IN-3物理化学性质

• 分子式: C₂₉H₃₀N₂O₅S
• 分子量: 518.62

MDM2/XIAP-IN-3靶点实验

查看更多实验

实验名称：Antitumor activity against human 22Rv1 cells xenografted in NOD SCID mouse assessed a... 来源：ChEMBL 靶标：CWR22R External Id：CHEMBL5322905

实验名称：Antitumor activity against human 22Rv1 cells xenografted in NOD SCID mouse at 60 mg/k... 来源：ChEMBL 靶标：CWR22R External Id：CHEMBL5322906

实验名称：Inhibition of MDM2 in human 22Rv1 cells assessed as increase in PARP expression upto ... 来源：ChEMBL 靶标：E3 ubiquitin-protein ligase Mdm2 External Id：CHEMBL5322903

实验名称：Inhibition of MDM2 in human A-375 cells assessed as increase in PARP expression upto ... 来源：ChEMBL 靶标：E3 ubiquitin-protein ligase Mdm2 External Id：CHEMBL5322904

实验名称：Inhibition of MDM2 in human 22Rv1 cells assessed as increase in p53 expression upto 1... 来源：ChEMBL 靶标：E3 ubiquitin-protein ligase Mdm2 External Id：CHEMBL5322901

实验名称：Inhibition of MDM2 in human A-375 cells assessed as increase in p53 expression upto 1... 来源：ChEMBL 靶标：E3 ubiquitin-protein ligase Mdm2 External Id：CHEMBL5322902

实验名称：Inhibition of XIAP in human EU-1 cells assessed as increase in caspase-9 at 1 uM incu... 来源：ChEMBL 靶标：E3 ubiquitin-protein ligase XIAP External Id：CHEMBL5322899

实验名称：Inhibition of XIAP in human EU-1 cells assessed as increase in PARP at 1 uM incubated... 来源：ChEMBL 靶标：E3 ubiquitin-protein ligase XIAP External Id：CHEMBL5322900

实验名称：Inhibition of MDM2 in human EU-1 cells assessed as increase in PUMA expression upto 1... 来源：ChEMBL 靶标：E3 ubiquitin-protein ligase Mdm2 External Id：CHEMBL5322897

实验名称：Inhibition of XIAP in human EU-1 cells assessed as increase in caspase3 at 1 uM incub... 来源：ChEMBL 靶标：E3 ubiquitin-protein ligase XIAP External Id：CHEMBL5322898

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