Tubulin polymerization-IN-55

• 常用名: Tubulin polymerization-IN-55
• 英文名: Tubulin polymerization-IN-55
• CAS号: 2942396-29-2
• 分子量: 380.44
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₂₄N₂O₄
• 熔点: N/A
• 闪点: N/A

Tubulin polymerization-IN-55用途

Tubulin polymerization-IN-55 是 Tubulin Polymerization 的有效抑制剂。Tubulin polymerization-IN-55 对 A549、K562、HepG2、MDA-MB-231 和 HFL-1 具有抗增殖活性,其 IC50 分别为 8、3、9、24 和 62 nM。

Tubulin polymerization-IN-55名称

• 英文名: Tubulin polymerization-IN-55

Tubulin polymerization-IN-55生物活性

• 描述: Tubulin polymerization-IN-55 是 Tubulin Polymerization 的有效抑制剂。Tubulin polymerization-IN-55 对 A549、K562、HepG2、MDA-MB-231 和 HFL-1 具有抗增殖活性,其 IC50 分别为 8、3、9、24 和 62 nM。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> 微管/微管蛋白
  信号通路 >> 细胞骨架 >> 微管/微管蛋白
• 参考文献:

  [1]. Tan Y, et al. Design, synthesis and biological evaluation of novel dihydroquinolin-4(1H)-one derivatives as novel tubulin polymerization inhibitors. Eur J Med Chem. 2023 Oct 15;262:115881.

Tubulin polymerization-IN-55物理化学性质

• 分子式: C₂₂H₂₄N₂O₄
• 分子量: 380.44
• 储存条件: -20℃

Tubulin polymerization-IN-55靶点实验

查看更多实验

实验名称：Anti-angiogenesis activity in HUVEC cells assessed as disruption of capillary tube st... 来源：ChEMBL 靶标：HUVEC External Id：CHEMBL5637886

实验名称：Aqueous solubility of the compound by HPLC analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5637887

实验名称：Metabolic stability in mouse plasma assessed as half life at 1 uM and measured upto 3... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5637888

实验名称：Metabolic stability in mouse liver microsomes assessed as half life at 100 uM measure... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5637889

实验名称：Metabolic stability in mouse liver microsomes assessed as intrinsic clearance at 100 ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5637890

实验名称：Antitumor activity against mouse H22 cells allografted in mouse model assessed as inh... 来源：ChEMBL 靶标：H22 External Id：CHEMBL5637891

实验名称：Antitumor activity against mouse H22 cells allografted in mouse model assessed as inh... 来源：ChEMBL 靶标：H22 External Id：CHEMBL5637892

实验名称：Antitumor activity against mouse H22 cells allografted in mouse model assessed as tum... 来源：ChEMBL 靶标：H22 External Id：CHEMBL5637893

实验名称：Toxicity in mouse assessed as effect on body weight loss at 20 mg/kg, iv administered... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5637894

实验名称：Toxicity in mouse assessed as effect on heart at 20 mg/kg by H and E staining based m... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5637895

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