CIL56

• 常用名: CIL56
• 英文名: CA3(CIL56)
• CAS号: 300802-28-2
• 分子量: 489.608
• 密度: 1.5±0.1 g/cm3
• 沸点: 741.7±70.0 °C at 760 mmHg
• 分子式: C₂₃H₂₇N₃O₅S₂
• 熔点: N/A
• 闪点: 402.4±35.7 °C

CIL56用途

CIL56 是一种有效的选择性ferroptosis 诱导剂。Ferroptosis 是铁依赖性的调控细胞死亡 (RCD) 的非细胞凋亡形式。

CIL56名称

• 中文名: CIL56
• 英文名: 2,7-Bis-(piperidine-1-sulfonyl)-fluoren-9-one oxime

CIL56生物活性

• 描述: CIL56 是一种有效的选择性ferroptosis 诱导剂。Ferroptosis 是铁依赖性的调控细胞死亡 (RCD) 的非细胞凋亡形式。
• 相关类别:
  信号通路 >> 细胞凋亡 >> Ferroptosis
  研究领域 >> 癌症
• 体外研究: Ferroptosis是在癌细胞,肾细胞和神经元中观察到的非细胞凋亡形式的受调节细胞死亡.CIL56诱导铁依赖性活性氧(ROS)。抗氧化剂和铁螯合剂只能抑制低浓度CIL56的致死率[1]。 CIL56触发细胞死亡依赖于限速从头脂质合成酶ACC1。使用质谱法,分析用载体处理的对照与CIL56(6.5μM)±TOFA(4μM)处理的HT-1080细胞的代谢组。 。在该分析中鉴定的298种极性和非极性代谢物中,通过CIL56处理显着改变了141种代谢物的水平,82种代谢物显着增加,59种显着降低(FDR q <0.01)。 CIL56触发所有可检测的长链饱和和单不饱和脂肪酸以及所有可检测的多不饱和脂肪酸的TOFA敏感积累。考虑到非必需脂肪酸和必需脂肪酸物质积累的合理模型是CIL56通过线粒体β-氧化抑制脂肪酸的正常分解。 CIL56加速了ACC1依赖性丙二酰辅酶A的产生,丙二酰辅酶A是一种代谢物,可作为该过程的负调节因子[2]。
• 参考文献:

  [1]. Shimada K, et al. Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis. Nat Chem Biol. 2016 Jul;12(7):497-503.

  [2]. Dixon SJ, et al. Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death. ACS Chem Biol. 2015 Jul 17;10(7):1604-9.

CIL56物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 741.7±70.0 °C at 760 mmHg
• 分子式: C₂₃H₂₇N₃O₅S₂
• 分子量: 489.608
• 闪点: 402.4±35.7 °C
• 精确质量: 489.139221
• LogP: 3.66
• InChIKey: XYZXEEIUKQGUHB-UHFFFAOYSA-N
• SMILES: O=S(=O)(c1ccc2c(c1)C(=NO)c1cc(S(=O)(=O)N3CCCCC3)ccc1-2)N1CCCCC1
• 外观性状: 粉末
• 蒸汽压: 0.0±2.6 mmHg at 25°C
• 折射率: 1.714
• 储存条件: -20℃

CIL56靶点实验

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实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：HSF-1 induced GFP reporter and Doxycycline induced RFP reporter Measured in Cell-Base... 来源：Broad Institute 靶标：Hsf1 protein External Id：2038-03_Inhibitor_Dose_CherryPick_Activity_Set4

实验名称：Confirmed inhibitors of the Cav3 T-type Calcium Channel 来源：1043 靶标：voltage-dependent T-type calcium channel subunit alpha-1H isoform a [Homo sapiens] External Id：SAID_463087

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

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CIL56英文别名

• 2,7-Bis-(piperidine-1-sulfonyl)-fluoren-9-one oxime
• 9H-Fluoren-9-one, 2,7-bis(1-piperidinylsulfonyl)-, oxime
• N-Hydroxy-2,7-bis(1-piperidinylsulfonyl)-9H-fluoren-9-imine