PI3Kα-IN-11

• 常用名: PI3Kα-IN-11
• 英文名: PI3Kα-IN-11
• CAS号: 300803-79-6
• 分子量: 294.30
• 密度: 1.4±0.1 g/cm3
• 沸点: 622.4±55.0 °C at 760 mmHg
• 分子式: C₁₇H₁₄N₂O₃
• 熔点: N/A
• 闪点: 330.2±31.5 °C

PI3Kα-IN-11用途

PI3Kα-IN-11是一种具有抗癌活性的强效PI3Kβ抑制剂[1]。

PI3Kα-IN-11名称

• 英文名: WAY-299017

PI3Kα-IN-11生物活性

• 描述: PI3Kα-IN-11是一种具有抗癌活性的强效PI3Kβ抑制剂[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> PI3K/Akt/mTOR 信号通路 >> PI3K
• 靶点实验:

  PI3Kα

• 体外研究: 抑制 HCT116-WT和 HCT116-MUT(H1047R)细胞株的 IC50分别为 1.1和 0.73μM
• 参考文献:

  [1]. Sabbah DA, et al.N-Phenyl-4-hydroxy-2-quinolone-3-carboxamides as selective inhibitors of mutant H1047R phosphoinositide-3-kinase (PI3Kα). Bioorg Med Chem. 2012 Dec 15;20(24):7175-83.

PI3Kα-IN-11物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 622.4±55.0 °C at 760 mmHg
• 分子式: C₁₇H₁₄N₂O₃
• 分子量: 294.30
• 闪点: 330.2±31.5 °C
• 精确质量: 294.100433
• LogP: 1.04
• InChIKey: WKAZEVUZAKRWHB-UHFFFAOYSA-N
• SMILES: O=C(NCc1ccccc1)c1c(O)c2ccccc2[nH]c1=O
• 蒸汽压: 0.0±1.9 mmHg at 25°C
• 折射率: 1.667
• 储存条件: -80℃储存

PI3Kα-IN-11靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens] External Id：SIAE_INH_FP_1536_1X%INH PRUN

实验名称：uHTS identification of small molecule modulators of NR3A 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：SBCCG-A1015-NR3A-Primary-Assay

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PI3Kα-IN-11英文别名

• N-Benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamide
• N-Benzyl-4-hydroxy-2-oxo-1,2-dihydro-3-quinolinecarboxamide
• 4-Hydroxy-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid benzylamide