GSA 10

• 常用名: GSA 10
• 英文名: GSA-10
• CAS号: 300833-95-8
• 分子量: 450.527
• 密度: 1.240±0.06 g/cm3
• 沸点: 620.2±55.0 °C at 760 mmHg
• 分子式: C₂₆H₃₀N₂O₅
• 熔点: N/A
• 闪点: 328.9±31.5 °C
• 符号: GHS07
• 信号词: Warning

GSA 10用途

GSA-10是平滑(Smo)受体的有效激动剂,EC50为1.2μM。GSA-10是一种新型喹啉甲酰胺衍生物。GSA-10作用于Smo,促进多能间充质祖细胞向成骨细胞分化。GSA-10介导Hedgehog(Hh)信号,这可能对癌症疾病的再生医学有研究兴趣[1][2]。

GSA 10名称

• 中文名: 4-[[(1-己基-1,2-二氢-4-羟基-2-氧代-3-喹啉基)羰基]氨基]苯甲酸丙酯
• 英文名: propyl 4-(1-hexyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)benzoate

GSA 10生物活性

• 描述: GSA-10是平滑(Smo)受体的有效激动剂,EC50为1.2μM。GSA-10是一种新型喹啉甲酰胺衍生物。GSA-10作用于Smo,促进多能间充质祖细胞向成骨细胞分化。GSA-10介导Hedgehog(Hh)信号,这可能对癌症疾病的再生医学有研究兴趣[1][2]。
• 相关类别:
  信号通路 >> 干细胞及 Wnt 通路 >> SMO
  研究领域 >> 癌症
• 靶点实验:

  Smoothened receptor[1]

• 参考文献:

  [1]. Manetti F, et al. Design, synthesis and biological characterization of a new class of osteogenic (1H)-quinolone derivatives. Eur J Med Chem. 2016;121:747-757.

  [2]. Gorojankina T, et al. Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened [published correction appears in Mol Pharmacol. 2013 Aug;84(2):303]. Mol Pharmacol. 2013;83(5):1020-1029.

GSA 10物理化学性质

• 密度: 1.240±0.06 g/cm3
• 沸点: 620.2±55.0 °C at 760 mmHg
• 分子式: C₂₆H₃₀N₂O₅
• 分子量: 450.527
• 闪点: 328.9±31.5 °C
• 精确质量: 450.215485
• PSA: 97.63000
• LogP: 5.79
• InChIKey: MDLUYYGRCGDKGL-UHFFFAOYSA-N
• SMILES: CCCCCCn1c(=O)c(C(=O)Nc2ccc(C(=O)OCCC)cc2)c(O)c2ccccc21
• 蒸汽压: 0.0±1.9 mmHg at 25°C
• 折射率: 1.610
• 水溶解性: Insuluble (4.1E-4 g/L) (25 ºC)

GSA 10安全信息

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302
• 危险品运输编码: NONH for all modes of transport

GSA 10靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A7681

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC External Id：APP-Toga-CHIKV-nsp2-p

实验名称：qHTS assay to identify novel small-molecules to repurpose for Merkel cell carcinoma t... 来源：NCGC 靶标：N/A External Id：MCC011

实验名称：Primary qHTS for Identification of Calcium Integrin Binding Protein 1 (CIB1) Competit... 来源：NCGC External Id：CIB1-p1-p2

实验名称：Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase... 来源：NCGC External Id：GPx1-biochemical-p4-p7

实验名称：Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screeni... 来源：NCGC 靶标：N/A External Id：CPF001

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GSA 10英文别名

• Propyl 4-{[(1-hexyl-4-hydroxy-2-oxo-1,2-dihydro-3-quinolinyl)carbonyl]amino}benzoate
• Benzoic acid, 4-[[(1-hexyl-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinyl)carbonyl]amino]-, propyl ester
• propyl 4-{[(1-hexyl-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)carbonyl]amino}benzoate
• GSA 10
• 4-[[(1-Hexyl-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinyl)carbonyl]amino]benzoic acid propyl ester