GSA-10

Modify Date: 2024-01-03 17:36:44

GSA-10 structure	Common Name	GSA-10
	CAS Number	300833-95-8	Molecular Weight	450.527
	Density	1.240±0.06 g/cm3	Boiling Point	620.2±55.0 °C at 760 mmHg
	Molecular Formula	C₂₆H₃₀N₂O₅	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	328.9±31.5 °C
	Symbol	GHS07	Signal Word	Warning

Use of GSA-10

GSA-10 is a potent agonist of Smoothened (Smo) receptor with an EC50 of 1.2 μM. GSA-10 is a novel quinolinecarboxamide derivative. GSA-10 acts at Smo to promote the differentiation of multipotent mesenchymal progenitor cells into osteoblasts. GSA-10 mediates Hedgehog (Hh) signaling which may have researching interests in regenerative medicine for cancer disease[1][2].

Name	propyl 4-(1-hexyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)benzoate
Synonym	More Synonyms

Description	GSA-10 is a potent agonist of Smoothened (Smo) receptor with an EC50 of 1.2 μM. GSA-10 is a novel quinolinecarboxamide derivative. GSA-10 acts at Smo to promote the differentiation of multipotent mesenchymal progenitor cells into osteoblasts. GSA-10 mediates Hedgehog (Hh) signaling which may have researching interests in regenerative medicine for cancer disease[1][2].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> Smo Research Areas >> Cancer
Target	Smoothened receptor[1]
References	[1]. Manetti F, et al. Design, synthesis and biological characterization of a new class of osteogenic (1H)-quinolone derivatives. Eur J Med Chem. 2016;121:747-757. [2]. Gorojankina T, et al. Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened [published correction appears in Mol Pharmacol. 2013 Aug;84(2):303]. Mol Pharmacol. 2013;83(5):1020-1029.

Density	1.240±0.06 g/cm3
Boiling Point	620.2±55.0 °C at 760 mmHg
Molecular Formula	C₂₆H₃₀N₂O₅
Molecular Weight	450.527
Flash Point	328.9±31.5 °C
Exact Mass	450.215485
PSA	97.63000
LogP	5.79
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.610
Water Solubility	Insuluble (4.1E-4 g/L) (25 ºC)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
RIDADR	NONH for all modes of transport

Propyl 4-{[(1-hexyl-4-hydroxy-2-oxo-1,2-dihydro-3-quinolinyl)carbonyl]amino}benzoate

Benzoic acid, 4-[[(1-hexyl-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinyl)carbonyl]amino]-, propyl ester

propyl 4-{[(1-hexyl-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)carbonyl]amino}benzoate

GSA 10

4-[[(1-Hexyl-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinyl)carbonyl]amino]benzoic acid propyl ester

DC Chemicals Limited
China
Product Name: GSA-10
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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