GSA-10

Modify Date: 2024-01-03 17:36:44

GSA-10 Structure
GSA-10 structure
Common Name GSA-10
CAS Number 300833-95-8 Molecular Weight 450.527
Density 1.240±0.06 g/cm3 Boiling Point 620.2±55.0 °C at 760 mmHg
Molecular Formula C26H30N2O5 Melting Point N/A
MSDS Chinese USA Flash Point 328.9±31.5 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of GSA-10


GSA-10 is a potent agonist of Smoothened (Smo) receptor with an EC50 of 1.2 μM. GSA-10 is a novel quinolinecarboxamide derivative. GSA-10 acts at Smo to promote the differentiation of multipotent mesenchymal progenitor cells into osteoblasts. GSA-10 mediates Hedgehog (Hh) signaling which may have researching interests in regenerative medicine for cancer disease[1][2].

 Names

Name propyl 4-(1-hexyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)benzoate
Synonym More Synonyms

 GSA-10 Biological Activity

Description GSA-10 is a potent agonist of Smoothened (Smo) receptor with an EC50 of 1.2 μM. GSA-10 is a novel quinolinecarboxamide derivative. GSA-10 acts at Smo to promote the differentiation of multipotent mesenchymal progenitor cells into osteoblasts. GSA-10 mediates Hedgehog (Hh) signaling which may have researching interests in regenerative medicine for cancer disease[1][2].
Related Catalog
Target

Smoothened receptor[1]

References

[1]. Manetti F, et al. Design, synthesis and biological characterization of a new class of osteogenic (1H)-quinolone derivatives. Eur J Med Chem. 2016;121:747-757.

[2]. Gorojankina T, et al. Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened [published correction appears in Mol Pharmacol. 2013 Aug;84(2):303]. Mol Pharmacol. 2013;83(5):1020-1029.

 Chemical & Physical Properties

Density 1.240±0.06 g/cm3
Boiling Point 620.2±55.0 °C at 760 mmHg
Molecular Formula C26H30N2O5
Molecular Weight 450.527
Flash Point 328.9±31.5 °C
Exact Mass 450.215485
PSA 97.63000
LogP 5.79
Vapour Pressure 0.0±1.9 mmHg at 25°C
Index of Refraction 1.610
Water Solubility Insuluble (4.1E-4 g/L) (25 ºC)

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
RIDADR NONH for all modes of transport

 Synonyms

Propyl 4-{[(1-hexyl-4-hydroxy-2-oxo-1,2-dihydro-3-quinolinyl)carbonyl]amino}benzoate
Benzoic acid, 4-[[(1-hexyl-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinyl)carbonyl]amino]-, propyl ester
propyl 4-{[(1-hexyl-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)carbonyl]amino}benzoate
GSA 10
4-[[(1-Hexyl-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinyl)carbonyl]amino]benzoic acid propyl ester
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