IQP-0528

• 常用名: IQP-0528
• 英文名: IQP-0528
• CAS号: 301297-45-0
• 分子量: 340.42
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₂₄N₂O₃
• 熔点: N/A
• 闪点: N/A

IQP-0528用途

IQP-0528是一种高效的非核苷逆转录酶抑制剂(NNRTI)。IQP-0528显示出针对HIV-1和HIV-2的纳摩尔活性,HIV-1 EC50为0.2 nM,HIV-2 EC50为100 nM[1]。

IQP-0528名称

• 英文名: 1-(cyclopropylmethyl)-6-(3,5-dimethylbenzoyl)-5-propan-2-ylpyrimidine-2,4-dione

IQP-0528生物活性

• 描述: IQP-0528是一种高效的非核苷逆转录酶抑制剂(NNRTI)。IQP-0528显示出针对HIV-1和HIV-2的纳摩尔活性,HIV-1 EC50为0.2 nM,HIV-2 EC50为100 nM[1]。
• 相关类别:
  信号通路 >> 抗感染 >> HIV
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 逆转录酶
• 参考文献:

  [1]. Su JT, et al. A Dose Ranging Pharmacokinetic Evaluation of IQP-0528 Released from Intravaginal Rings in Non-Human Primates. Pharm Res. 2017;34(10):2163-2171.

IQP-0528物理化学性质

• 分子式: C₂₀H₂₄N₂O₃
• 分子量: 340.42
• 精确质量: 340.17900
• PSA: 72.19000
• LogP: 3.33010
• InChIKey: UCOAKFIVSAVHLC-UHFFFAOYSA-N
• SMILES: Cc1cc(C)cc(C(=O)c2c(C(C)C)c(=O)[nH]c(=O)n2CC2CC2)c1

IQP-0528靶点实验

查看更多实验

实验名称：Antiviral activity against HIV1 infected in human CEM-SS cells assessed as inhibition... 来源：ChEMBL 靶标：Human immunodeficiency virus 1 External Id：CHEMBL1054767

实验名称：Cytotoxicity against human HeLa cells expressing CD4-LTR by XTT assay 来源：ChEMBL 靶标：HeLa External Id：CHEMBL1054763

实验名称：Therapeutic index, ratio of TC50 human HeLa cells expressing CD4-LTR to EC50 for HIV1... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1054764

实验名称：Antiviral activity against SIV MAC251 infected in human 174xCEM cells assessed as inh... 来源：ChEMBL 靶标：Simian immunodeficiency virus External Id：CHEMBL1054777

实验名称：HIV Enzyme Data 来源：NIAID 靶标：N/A External Id：HIV Enzyme Data

实验名称：Inhibition of HIV2 reverse transcriptase assessed as 32P-labeled GMP incorporation in... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1054775

实验名称：Inhibition of HIV1 gp120/CD4 interaction assessed as inhibition of gp120 and gp41 coe... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1054776

实验名称：Antiviral activity against HIV2 assessed as inhibition of viral single round replicat... 来源：ChEMBL 靶标：Human immunodeficiency virus 2 External Id：CHEMBL1054773

实验名称：Antiviral activity against HIV2 assessed as inhibition of viral replication treated a... 来源：ChEMBL 靶标：Human immunodeficiency virus 2 External Id：CHEMBL1054774

实验名称：HIV Cellular Data 来源：NIAID 靶标：N/A External Id：HIV Cellular Data

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IQP-0528英文别名

• 1-(cyclopropylmethyl)-6-(3,5-dimethylbenzoyl)-5-(propan-2-yl)pyrimidine-2,4(1h,3h)-dione
• 2,4(1H,3H)-Pyrimidinedione,1-(cyclopropylmethyl)-6-(3,5-dimethylbenzoyl)-5-isopropyl
• UNII-1Y42TZL33O
• IQP-528
• IQP-0528