去甲氯米帕明 盐酸盐
去甲氯米帕明 盐酸盐结构式
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常用名 | 去甲氯米帕明 盐酸盐 | 英文名 | Didemethylclomipramine |
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| CAS号 | 303-48-0 | 分子量 | 337.28700 | |
| 密度 | 1.129g/cm3 | 沸点 | 439.5ºC at 760mmHg | |
| 分子式 | C18H22Cl2N2 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 219.6ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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Steady state concentrations of clomipramine and its major metabolite desmethylclomipramine in rat brain and serum after oral administration of clomipramine.
Eur. Neuropsychopharmacol. 10(5) , 401-5, (2000) Twenty male Sprague-Dawley rats received five oral doses of clomipramine 20 mg/kg at 4-h intervals. The animals were decapitated 1, 2, 3, 5 and 12 h after the last dose for determination of clomipramine and desmethylclomipramine in serum and frontal cerebral ... |
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Clinical significance of plasma levels of clomipramine, its hydroxylated and desmethylated metabolites: prediction of clinical outcome in mood disorders using discriminant analysis of therapeutic drug monitoring data.
J. Affect. Disord. 29(4) , 267-79, (1993) We measured the plasma concentrations of clomipramine and its metabolites, N-desmethylclompiramine, 8-hydroxy-N-desmethylclomipramine, 8-hydroxyclomipramine in 65 depressed patients with subtypes of DSM-III-R mood disorders receiving clomipramine hydrochlorid... |
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Pharmacokinetics of clomipramine in dogs following single-dose and repeated-dose oral administration.
Am. J. Vet. Res. 61(1) , 80-5, (2000) To determine pharmacokinetics of clomipramine and its principle metabolite (desmethylclomipramine) in the plasma of dogs following single-dose and repeated-dose oral administration at various dosages.9 male and 9 female Beagles.Clomipramine was administered o... |
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Simultaneous plasma level analysis of clomipramine, N-desmethylclomipramine, and fluvoxamine by reversed-phase liquid chromatography.
Ther. Drug Monit. 22(2) , 190-4, (2000) A simple reversed-phase liquid chromatographic method enabling the simultaneous analysis in plasma of the tricyclic antidepressant clomipramine, its demethylated metabolite, and the selective serotonin reuptake inhibitor fluvoxamine, was developed. The drugs ... |
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Simultaneous analysis of clozapine, clomipramine and their metabolites by reversed-phase liquid chromatography.
Prog. Neuropsychopharmacol. Biol. Psychiatry 25(3) , 519-33, (2001) 1. The authors present here a sensitive and rapid reversed-phase liquid chromatographic method which enables the simultaneous analysis in plasma of two different drugs and their metabolites: the atypical neuroleptic clozapine and the tricyclic antidepressant ... |
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Increased antipanic efficacy in combined treatment with clomipramine and dixyrazine.
Acta Psychiatr. Scand. 89(4) , 230-4, (1994) A double-blind 12 week trial was undertaken to compare the effects of clomipramine + dixyrazine with clomipramine + placebo in the treatment of panic disorder with or without agoraphobia. Of 45 patients included (21 dixyrazine, 24 placebo), 16 dropped out (6 ... |
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Pharmacokinetics of clomipramine in dogs following single-dose intravenous and oral administration.
Am. J. Vet. Res. 61(1) , 74-9, (2000) To determine pharmacokinetics of clomipramine and its principle metabolite (desmethylclomipramine) in the plasma of dogs after IV or oral administration of a single dose.6 male and 6 female Beagles.Clomipramine was administered IV (2 mg/kg), PO (4 mg/kg) afte... |
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Application of HPLC with silica-phase and reversed-phase eluents for the determination of clomipramine and demethylated and 8-hydroxylated metabolites.
J. Anal. Toxicol. 20(2) , 101-5, (1996) A rapid and efficient high-performance liquid chromatographic method using a reversed-phase eluent of methanol-water with butylamine on a silica column was developed for the separation and quantitation of clomipramine (CMI), its demethylated metabolites (desm... |
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Citalopram: an interaction study with clomipramine in a patient heterozygous for CYP2D6 genotype.
Pharmacopsychiatry 32(6) , 232-4, (1999) A pharmacokinetic interaction between the selective serotonin reuptake inhibitor citalopram and a tricyclic antidepressant, clomipramine, was noted in a patient treated for major depression and obsessive-compulsive disorder. After the addition of citalopram, ... |
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Regional distribution of clomipramine and desmethylclomipramine in rat brain and peripheral organs on chronic clomipramine administration.
J. Psychopharmacol. 24(8) , 1261-8, (2010) The tricyclic antidepressant (TCA) clomipramine has been widely used in psychiatry for over 40 years. More recently, its therapeutic potential as an antineoplastic drug has been identified. However, there are no prior data on regional distribution in the brai... |