(E)-N-(4-苄基-1-哌嗪基)-1-(3,5-二甲基-1-苯基-1H-吡唑-4-基)甲亚胺结构式
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常用名 | (E)-N-(4-苄基-1-哌嗪基)-1-(3,5-二甲基-1-苯基-1H-吡唑-4-基)甲亚胺 | 英文名 | SANT-1 |
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| CAS号 | 304909-07-7 | 分子量 | 373.49 | |
| 密度 | 1.13g/cm3 | 沸点 | 547.4ºC at 760mmHg | |
| 分子式 | C23H27N5 | 熔点 | 104-106ºC | |
| MSDS | 中文版 美版 | 闪点 | 284.8ºC |
用途SANT-1 是一种有效的 Smo 拮抗剂,能够抑制 Hedgehog 通路,在 Shh-LIGHT2 和 SmoA1-LIGHT2 实验中,IC50 值分别为 20 nM 和 30 nM。 |
| 中文名 | (E)-N-(4-苄基-1-哌嗪基)-1-(3,5-二甲基-1-苯基-1H-吡唑-4-基)甲亚胺 |
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| 英文名 | (E)-N-(4-benzylpiperazin-1-yl)-1-(3,5-dimethyl-1-phenylpyrazol-4-yl)methanimine |
| 英文别名 | 更多 |
| 描述 | SANT-1 是一种有效的 Smo 拮抗剂,能够抑制 Hedgehog 通路,在 Shh-LIGHT2 和 SmoA1-LIGHT2 实验中,IC50 值分别为 20 nM 和 30 nM。 |
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| 相关类别 | |
| 靶点 |
IC50: 20 nM (Shh signaling), 30 nM (SmoA1)[1] |
| 参考文献 |
| 密度 | 1.13g/cm3 |
|---|---|
| 沸点 | 547.4ºC at 760mmHg |
| 熔点 | 104-106ºC |
| 分子式 | C23H27N5 |
| 分子量 | 373.49 |
| 闪点 | 284.8ºC |
| 精确质量 | 373.22700 |
| PSA | 36.66000 |
| LogP | 3.51660 |
| 外观性状 | 固体;White to Orange to Green powder to crystal |
| 折射率 | 1.623 |
| 储存条件 | −20°C |
| 水溶解性 | Soluble in DMSO with warming |
| 个人防护装备 | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| 危险品运输编码 | NONH for all modes of transport |
| 上游产品 0 | |
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| 下游产品 1 | |
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Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium.
PLoS ONE 4(4) , e5182, (2009) Activation of Hedgehog (Hh) signaling requires the transmembrane protein Smoothened (Smo), a member of the G-protein coupled receptor superfamily. In mammals, Smo translocates to the primary cilium up... |
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MicroRNA-602 and microRNA-608 regulate sonic hedgehog expression via target sites in the coding region in human chondrocytes.
Arthritis Rheumatology 67(2) , 423-34, (2015) Hedgehog (HH) signaling has recently been associated with cartilage degradation in osteoarthritis (OA). Because interleukin-1β (IL-1β) has been implicated as a principal instigator of OA, we sought to... |
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MRT-92 inhibits Hedgehog signaling by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor.
FASEB J. 29 , 1817-29, (2015) The Smoothened (Smo) receptor, a member of class F G protein-coupled receptors, is the main transducer of the Hedgehog (Hh) signaling pathway implicated in a wide range of developmental and adult proc... |
| (E)-N-(4-Benzylpiperazin-1-yl)-1-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methanimine |
| SANT-1 |
| (4-Benzyl-piperazin-1-yl)-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-ylmethylene)-amine |
| Shh Signaling Antagonist V |
| (E)-N-(4-Benzyl-1-piperazinyl)-1-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methanimine |
| 1-Piperazinamine (N-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl) |
| 1-Piperazinamine, N-[(1E)-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)- |
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CAS号39139-52-1