SANT-1

Modify Date: 2025-08-20 22:38:57

SANT-1 Structure
SANT-1 structure
Common Name SANT-1
CAS Number 304909-07-7 Molecular Weight 373.49
Density 1.13g/cm3 Boiling Point 547.4ºC at 760mmHg
Molecular Formula C23H27N5 Melting Point 104-106ºC
MSDS Chinese USA Flash Point 284.8ºC

 Use of SANT-1


SANT-1 is a potent Smo antagonist, inhibits Hedgehog signaling, with IC50s of 20 nM and 30 nM in Shh-LIGHT2 and SmoA1-LIGHT2 assay, respectively[1].

 Names

Name (E)-N-(4-benzylpiperazin-1-yl)-1-(3,5-dimethyl-1-phenylpyrazol-4-yl)methanimine
Synonym More Synonyms

 SANT-1 Biological Activity

Description SANT-1 is a potent Smo antagonist, inhibits Hedgehog signaling, with IC50s of 20 nM and 30 nM in Shh-LIGHT2 and SmoA1-LIGHT2 assay, respectively[1].
Related Catalog
Target

IC50: 20 nM (Shh signaling), 30 nM (SmoA1)[1]

References

[1]. Chen JK, et al. Small molecule modulation of Smoothened activity. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14071-6.

 Chemical & Physical Properties

Density 1.13g/cm3
Boiling Point 547.4ºC at 760mmHg
Melting Point 104-106ºC
Molecular Formula C23H27N5
Molecular Weight 373.49
Flash Point 284.8ºC
Exact Mass 373.22700
PSA 36.66000
LogP 3.51660
Index of Refraction 1.623
Storage condition −20°C
Water Solubility Soluble in DMSO with warming

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport

 Precursor & DownStream

Precursor  0

DownStream  1

 Articles13

More Articles
Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium.

PLoS ONE 4(4) , e5182, (2009)

Activation of Hedgehog (Hh) signaling requires the transmembrane protein Smoothened (Smo), a member of the G-protein coupled receptor superfamily. In mammals, Smo translocates to the primary cilium up...

MicroRNA-602 and microRNA-608 regulate sonic hedgehog expression via target sites in the coding region in human chondrocytes.

Arthritis Rheumatology 67(2) , 423-34, (2015)

Hedgehog (HH) signaling has recently been associated with cartilage degradation in osteoarthritis (OA). Because interleukin-1β (IL-1β) has been implicated as a principal instigator of OA, we sought to...

MRT-92 inhibits Hedgehog signaling by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor.

FASEB J. 29 , 1817-29, (2015)

The Smoothened (Smo) receptor, a member of class F G protein-coupled receptors, is the main transducer of the Hedgehog (Hh) signaling pathway implicated in a wide range of developmental and adult proc...

 Synonyms

(E)-N-(4-Benzylpiperazin-1-yl)-1-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methanimine
SANT-1
(4-Benzyl-piperazin-1-yl)-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-ylmethylene)-amine
Shh Signaling Antagonist V
(E)-N-(4-Benzyl-1-piperazinyl)-1-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methanimine
1-Piperazinamine (N-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)
1-Piperazinamine, N-[(1E)-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)-
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