GI 181771

更新时间：2025-11-30 12:09:56

GI 181771结构式	常用名	GI 181771	英文名	GI 181771
	CAS号	305366-98-7	分子量	605.64000
	密度	N/A	沸点	N/A
	分子式	C₃₄H₃₁N₅O₆	熔点	N/A
	MSDS	N/A	闪点	N/A

GI 181771用途

GI 181771是研究用于治疗肥胖症的胆囊收缩素1 (cholecystokinin 1) 受体激动剂。

中文名	GI 181771
英文名	3-[[(3S)-2,4-dioxo-1-[2-oxo-2-(N-propan-2-ylanilino)ethyl]-5-phenyl-1,5-benzodiazepin-3-yl]carbamoylamino]benzoic acid
英文别名	更多

描述	GI 181771是研究用于治疗肥胖症的胆囊收缩素1 (cholecystokinin 1) 受体激动剂。
相关类别	信号通路 >> G 蛋白偶联受体/G 蛋白 >> 胆囊收缩素受体研究领域 >> 代谢疾病
靶点实验	Target: Cholecystokinin 1 receptor[1]
参考文献	[1]. Myer JR, et al. Species- and dose-specific pancreatic responses and progression in single- and repeat-dose studies with GI181771X: a novel cholecystokinin 1 receptor agonist in mice, rats, and monkeys. Toxicol Pathol. 2014 Jan;42(1):260-74. [2]. Roses AD, et al. Stimulation of cholecystokinin-A receptors with Gl181771X: a failed clinical trial that did not test the pharmacogenetic hypothesis for reduction of food intake. Clin Pharmacol Ther. 2009 Apr;85(4):362-5.

分子式	C₃₄H₃₁N₅O₆
分子量	605.64000
精确质量	605.22700
PSA	142.85000
LogP	5.56250

实验名称：Antiobesity activity in Sprague-Dawley rat assessed as reduction in spontaneous food ...
来源：ChEMBL
靶标：Rattus norvegicus
External Id：CHEMBL1273780

实验名称：Agonist activity at CCK1R (unknown origin) expressed in CHO cells assessed as CCK res...
来源：ChEMBL
靶标：Cholecystokinin receptor type A
External Id：CHEMBL3413154

实验名称：Displacement of [125I]CCK8 from rat CCK1 receptor expressed in CHO cells
来源：ChEMBL
靶标：Cholecystokinin receptor type A
External Id：CHEMBL1273772

实验名称：Agonist activity at rat CCK1 receptor expressed in CHO cells assessed as induction of...
来源：ChEMBL
靶标：Cholecystokinin receptor type A
External Id：CHEMBL1273773

实验名称：Induction of emptying of gallbladder in C57BL/6J mouse at 6 mg/kg, po measured at 1 h...
来源：ChEMBL
靶标：Mus musculus
External Id：CHEMBL1273776

实验名称：Induction of emptying of gallbladder in C57BL/6J mouse at 6 mg/kg, po measured at 24 ...
来源：ChEMBL
靶标：Mus musculus
External Id：CHEMBL1273777

实验名称：Activity at CCK2R (unknown origin) expressed in CHO cells assessed as stimulation of ...
来源：ChEMBL
靶标：Gastrin/cholecystokinin type B receptor
External Id：CHEMBL3412208

实验名称：Biliary clearance in Sprague-Dawley rat assessed as parent compound excretion into bi...
来源：ChEMBL
靶标：Rattus norvegicus
External Id：CHEMBL1273798

实验名称：Lipophilicity, log D of the compound at pH 7.4
来源：ChEMBL
靶标：N/A
External Id：CHEMBL1273766

实验名称：Displacement of [125I]CCK8 from human CCK1 receptor expressed in CHO cells
来源：ChEMBL
靶标：Cholecystokinin receptor type A
External Id：CHEMBL1273767

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GI 181771