ICA-121431

• 常用名: ICA-121431
• 英文名: ICA 121431
• CAS号: 313254-51-2
• 分子量: 449.545
• 密度: 1.4±0.1 g/cm3
• 沸点: N/A
• 分子式: C₂₃H₁₉N₃O₃S₂
• 熔点: N/A
• 闪点: N/A
• 符号: GHS07
• 信号词: Warning

ICA-121431用途

ICA-121431是大鼠Nav1.7离子通道高效抑制剂,IC50值为19nM,但对人、狗以及小鼠的Nav1.7作用基本无。

ICA-121431名称

• 中文名: ICA-121431
• 英文名: Benzeneacetamide, α-​phenyl-​N-​[4-​[(2-​thiazolylamino)​sulfonyl]​phenyl]​

ICA-121431生物活性

• 描述: ICA-121431是大鼠Nav1.7离子通道高效抑制剂,IC50值为19nM,但对人、狗以及小鼠的Nav1.7作用基本无。
• 相关类别:
  信号通路 >> 跨膜转运 >> 钠通道
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. McCormack K, et al. Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels. Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):E2724-32.

ICA-121431物理化学性质

• 密度: 1.4±0.1 g/cm3
• 分子式: C₂₃H₁₉N₃O₃S₂
• 分子量: 449.545
• 精确质量: 449.086792
• PSA: 124.78000
• LogP: 3.89
• InChIKey: URSQNPPONHUJDL-UHFFFAOYSA-N
• SMILES: O=C(Nc1ccc(S(=O)(=O)Nc2nccs2)cc1)C(c1ccccc1)c1ccccc1
• 折射率: 1.693
• 储存条件: 2-8℃

ICA-121431安全信息

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302-H319-H413
• 警示性声明: P305 + P351 + P338
• 危险品运输编码: NONH for all modes of transport

ICA-121431靶点实验

查看更多实验

实验名称：Selectivity ratio of IC50 for human NaV1.4 to IC50 for human NaV1.3 来源：ChEMBL 靶标：N/A External Id：CHEMBL4257710

实验名称：Selectivity ratio of IC50 for human NaV1.2 to IC50 for human NaV1.3 来源：ChEMBL 靶标：N/A External Id：CHEMBL4257709

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Selectivity ratio of IC50 for human NaV1.6 to IC50 for human NaV1.3 来源：ChEMBL 靶标：N/A External Id：CHEMBL4257712

实验名称：Selectivity ratio of IC50 for human NaV1.5 to IC50 for human NaV1.3 来源：ChEMBL 靶标：N/A External Id：CHEMBL4257711

实验名称：Inhibition of human NaV1.7 来源：ChEMBL 靶标：Sodium channel protein type 9 subunit alpha External Id：CHEMBL4257705

实验名称：Selectivity ratio of IC50 for human NaV1.1 to IC50 for human NaV1.3 来源：ChEMBL 靶标：N/A External Id：CHEMBL4257708

实验名称：Inhibition of human NaV1.8 来源：ChEMBL 靶标：Sodium channel protein type 10 subunit alpha External Id：CHEMBL4257707

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Efflux ratio of permeability across basolateral to apical over apical to basolateral ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4257718

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ICA-121431英文别名

• 2,2-Diphenyl-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]acetamide
• ICA-121431