PD-118057

• 常用名: PD-118057
• 英文名: PD 118057
• CAS号: 313674-97-4
• 分子量: 386.27
• 密度: 1.353g/cm3
• 沸点: 527ºC at 760 mmHg
• 分子式: C₂₁H₁₇Cl₂NO₂
• 熔点: N/A
• 闪点: 272.52ºC
• 符号: GHS07
• 信号词: Warning

PD-118057用途

PD-118057 是一种 human ether-a-go-go-related gene (hERG) 通道激活剂,但不会导致 hERG 阻滞。

PD-118057名称

• 中文名: PD-118057
• 英文名: 2-[4-[2-(3,4-dichlorophenyl)ethyl]anilino]benzoic acid

PD-118057生物活性

• 描述: PD-118057 是一种 human ether-a-go-go-related gene (hERG) 通道激活剂,但不会导致 hERG 阻滞。
• 相关类别:
  研究领域 >> 代谢疾病
  信号通路 >> 跨膜转运 >> 钾通道
• 靶点实验:

  Human ether-a-go-go-related gene channel[1]

• 参考文献:

  [1]. Mao H, et al. Pharmacologic Approach to Defective Protein Trafficking in the E637K-hERG Mutant with PD-118057 and Thapsigargin. PLoS One. 2013 Jun 19;8(6):e65481.

PD-118057物理化学性质

• 密度: 1.353g/cm3
• 沸点: 527ºC at 760 mmHg
• 分子式: C₂₁H₁₇Cl₂NO₂
• 分子量: 386.27
• 闪点: 272.52ºC
• 精确质量: 385.06400
• PSA: 49.33000
• LogP: 6.29340
• InChIKey: ZCQOSCDABPVAFB-UHFFFAOYSA-N
• SMILES: O=C(O)c1ccccc1Nc1ccc(CCc2ccc(Cl)c(Cl)c2)cc1
• 折射率: 1.668
• 储存条件: -20°C， 密封， 干燥

PD-118057安全信息

• 符号: GHS07
• 信号词: Warning
• 危害声明: H315-H319-H335-H413
• 警示性声明: P261-P305 + P351 + P338
• 个人防护装备: dust mask type N95 (US);Eyeshields;Gloves
• 危险品运输编码: NONH for all modes of transport

PD-118057靶点实验

查看更多实验

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Activation of human TREK-1 expressed in CHO cells at 10 uM in presence of ML335 by pa... 来源：ChEMBL 靶标：Potassium channel subfamily K member 2 External Id：CHEMBL5125923

实验名称：Inhibition of amyloid beta (1 to 42) aggregation after 24 hrs by Thioflavin-T fluores... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2176106

实验名称：qHTS for Inhibitors of Polymerase Kappa 来源：NCGC 靶标：DNA polymerase kappa [Homo sapiens] External Id：PolK100

实验名称：Human Kv11.1 (Voltage-gated potassium channels) 来源：IUPHAR-DB 靶标：Kv11.1 (Voltage-gated potassium channels) [Homo sapiens] External Id：572_Human

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

实验名称：Enzymatic assay of human HDAC6 with custom peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808150

实验名称：Reduction in mean senile plaque area in Tg2576 mouse overexpressing human betaAPP695S... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL993093

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PD-118057英文别名

• 2-[[4-[2-(3,4-Dichlorophenyl)ethyl]phenyl]amino]benzoic acid