桑尼非拉姆

• 常用名: 桑尼非拉姆
• 英文名: DM 235
• CAS号: 314728-85-3
• 分子量: 246.305
• 密度: 1.2±0.1 g/cm3
• 沸点: 442.0±38.0 °C at 760 mmHg
• 分子式: C₁₄H₁₈N₂O₂
• 熔点: N/A
• 闪点: 205.0±19.1 °C

桑尼非拉姆用途

Sunifiram (DM-235)是ampakine样化合物,具有较piracetam更好的益智活性。

桑尼非拉姆名称

• 中文名: 1-(4-苯甲酰基哌嗪-1-基)-1-丙酮
• 英文名: 1-(4-benzoylpiperazin-1-yl)propan-1-one

桑尼非拉姆生物活性

• 描述: Sunifiram (DM-235)是ampakine样化合物,具有较piracetam更好的益智活性。
• 相关类别:
  信号通路 >> 跨膜转运 >> iGluR
  信号通路 >> 神经信号通路 >> iGluR
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Galeotti N, et al. AMPA-receptor activation is involved in the antiamnesic effect of DM 232 (unifiram) and DM 235 (sunifiram). Naunyn Schmiedebergs Arch Pharmacol. 2003 Dec;368(6):538-45.

  [2]. Moriguchi S, et al. Novel nootropic drug sunifiram enhances hippocampal synaptic efficacy via glycine-binding site of N-methyl-D-aspartate receptor. Hippocampus. 2013 Jun 3.

  [3]. Moriguchi S, et al. Novel nootropic drug sunifiram improves cognitive deficits via CaM kinase II and protein kinase C activation in olfactory bulbectomized mice. Behav Brain Res. 2013 Apr 1;242:150-7.

桑尼非拉姆物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 442.0±38.0 °C at 760 mmHg
• 分子式: C₁₄H₁₈N₂O₂
• 分子量: 246.305
• 闪点: 205.0±19.1 °C
• 精确质量: 246.136826
• PSA: 40.62000
• LogP: 0.26
• InChIKey: DGOWDUFJCINDGI-UHFFFAOYSA-N
• SMILES: CCC(=O)N1CCN(C(=O)c2ccccc2)CC1
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.561
• 储存条件: 2-8℃

桑尼非拉姆安全信息

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危险品运输编码: NONH for all modes of transport

桑尼非拉姆靶点实验

查看更多实验

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay 来源：ChEMBL 靶标：N/A External Id：CHEMBL1266185

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Cognition enhancing activity in sc dosed mouse assessed as reversal of scopolamine-in... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3404313

实验名称：Stability in human plasma by LC-MS/MS analysis 来源：ChEMBL 靶标：Plasma External Id：CHEMBL3404314

实验名称：Dicer-mediated maturation of pre-microRNA 来源：Center for Chemical Genomics, University of Michigan 靶标：N/A External Id：TargetID_659_CEMA

实验名称：Stability in phosphate buffer by LC-MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL3404315

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens] External Id：SIAE_INH_FP_1536_1X%INH PRUN

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桑尼非拉姆英文别名

• 1-(4-Benzoyl-1-piperazinyl)-1-propanone
• 1-(4-Benzoylpiperazin-1-yl)propan-1-one
• Lopac-D-5689
• DM 235
• DM-235
• Sunifiram