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桑尼非拉姆

桑尼非拉姆用途

Sunifiram (DM-235)是ampakine样化合物，具有较piracetam更好的益智活性。

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桑尼非拉姆名称

[ CAS 号 ]:
314728-85-3

[ 中文名 ]:
1-(4-苯甲酰基哌嗪-1-基)-1-丙酮

[ 英文名 ]:
DM 235

[英文别名 ]:

1-(4-Benzoyl-1-piperazinyl)-1-propanone
1-(4-Benzoylpiperazin-1-yl)propan-1-one
Lopac-D-5689
DM 235
DM-235
1-Propanone, 1-(4-benzoyl-1-piperazinyl)-
Sunifiram

桑尼非拉姆生物活性

[ 描述 ]:

Sunifiram (DM-235)是ampakine样化合物,具有较piracetam更好的益智活性。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> iGluR

信号通路 >> 神经信号通路 >> iGluR

研究领域 >> 神经疾病

[参考文献]

[1]. Galeotti N, et al. AMPA-receptor activation is involved in the antiamnesic effect of DM 232 (unifiram) and DM 235 (sunifiram). Naunyn Schmiedebergs Arch Pharmacol. 2003 Dec;368(6):538-45.

[2]. Moriguchi S, et al. Novel nootropic drug sunifiram enhances hippocampal synaptic efficacy via glycine-binding site of N-methyl-D-aspartate receptor. Hippocampus. 2013 Jun 3.

[3]. Moriguchi S, et al. Novel nootropic drug sunifiram improves cognitive deficits via CaM kinase II and protein kinase C activation in olfactory bulbectomized mice. Behav Brain Res. 2013 Apr 1;242:150-7.

[相关活性小分子]

桑尼非拉姆物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
442.0±38.0 °C at 760 mmHg

[ 分子式 ]:
C₁₄H₁₈N₂O₂

[ 分子量 ]:
246.305

[ 闪点 ]:
205.0±19.1 °C

[ 精确质量 ]:
246.136826

[ PSA ]:
40.62000

[ LogP ]:
0.26

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.561

[ 储存条件 ]:
2-8℃

桑尼非拉姆安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

桑尼非拉姆文献

Molecular simplification of 1,4-diazabicyclo[4.3.0]nonan-9-ones gives piperazine derivatives that maintain high nootropic activity.

J. Med. Chem. 43 , 4499, (2000)

Several 4-substituted 1-acylpiperazines, obtained by molecular simplification of 4-substituted 1,4-diazabicyclo[4.3.0]nonan-9-ones, have been synthesized and tested in vivo on the mouse passive avoida...

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