BRD 4354

• 常用名: BRD 4354
• 英文名: BRD 4354
• CAS号: 315698-07-8
• 分子量: 382.89
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₂₃ClN₄O
• 熔点: N/A
• 闪点: N/A

BRD 4354用途

BRD 4354 是 HDAC5 和 HDAC9 适度抑制剂,其 IC50 值分别为 0.85,1.88 μM。

BRD 4354作用

体外活性：BRD 4354是HDAC5和HDAC9的中等效力抑制剂，BRD4354的半最大抑制浓度（IC50）分别为0.85μM和1.88μM。 BRD 4354还在较高浓度（3.88-13.8μM）下抑制HDAC 4,6,7和8，但对其他I类HDAC 1,2和3的抑制作用较小（IC50>40μM）。

BRD 4354名称

• 中文名: BRD 4354
• 英文名: BRD 4354

BRD 4354生物活性

• 描述: BRD 4354 是 HDAC5 和 HDAC9 适度抑制剂,其 IC50 值分别为 0.85,1.88 μM。
• 相关类别:
  研究领域 >> 癌症
• 靶点实验:

  HDAC5:0.85 μM (IC50)

  HDAC9:1.88 μM (IC50)

• 体外研究: BRD 4354是HDAC5和HDAC9的中等有效抑制剂,BRD4354的半最大抑制浓度(IC50)分别为0.85μM和1.88μM。 BRD 4354还在较高浓度(3.88-13.8μM)下抑制HDAC 4,6,7和8,但对其他I类HDAC 1,2和3(IC50>40μM)的抑制作用较小[1]。
• 细胞实验: 用BRD 4354以10μM处理A549腺癌细胞24小时，将前50个上调和前50个下调基因与涉及药物的其他化合物处理，具有已建立的MoA的生物活性化合物和新型合成化合物进行比较[1]。
• 参考文献:

  [1]. Boskovic ZV, ET AL. Inhibition of Zinc-Dependent Histone Deacetylases with a Chemically Triggered Electrophile. ACS Chem Biol. 2016 Jul 15;11(7):1844-51.

BRD 4354物理化学性质

• 分子式: C₂₁H₂₃ClN₄O
• 分子量: 382.89
• InChIKey: XAFSFXYJOJWLJD-UHFFFAOYSA-N
• SMILES: CCN1CCN(C(c2cccnc2)c2cc(Cl)c3cccnc3c2O)CC1
• 储存条件: 2-8℃

BRD 4354靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：HSF-1 induced GFP reporter and Doxycycline induced RFP reporter Measured in Cell-Base... 来源：Broad Institute 靶标：Hsf1 protein External Id：2038-03_Inhibitor_Dose_CherryPick_Activity_Set4

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens] External Id：SIAE_INH_FP_1536_1X%INH PRUN

共122条，当前第1页，共13页

1

2

3

4

5