红松内酯

• 常用名: 红松内酯
• 英文名: pinusolide
• CAS号: 31685-80-0
• 分子量: 346.461
• 密度: 1.1±0.1 g/cm3
• 沸点: 465.3±38.0 °C at 760 mmHg
• 分子式: C₂₁H₃₀O₄
• 熔点: N/A
• 闪点: 228.5±25.2 °C

红松内酯用途

松果内酯是一种已知的血小板活化因子(PAF)受体结合拮抗剂。松果内酯不仅能降低肿瘤细胞的增殖活性,而且能特异性诱导凋亡[1]。

红松内酯名称

• 中文名: 红松内酯
• 英文名: methyl (1S,4aR,5S,8aR)-1,4a-dimethyl-6-methylidene-5-[2-(5-oxo-2H-furan-4-yl)ethyl]-3,4,5,7,8,8a-hexahydro-2H-naphthalene-1-carboxylate

红松内酯生物活性

• 描述: 松果内酯是一种已知的血小板活化因子(PAF)受体结合拮抗剂。松果内酯不仅能降低肿瘤细胞的增殖活性,而且能特异性诱导凋亡[1]。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
• 参考文献:

  [1]. Shults EE, et al. Gram-scale synthesis of pinusolide and evaluation of its antileukemic potential. Bioorg Med Chem Lett. 2006;16(16):4228-4232.

红松内酯物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 465.3±38.0 °C at 760 mmHg
• 分子式: C₂₁H₃₀O₄
• 分子量: 346.461
• 闪点: 228.5±25.2 °C
• 精确质量: 346.214417
• PSA: 52.60000
• LogP: 4.52
• InChIKey: WTKBZJAWPZXKJU-NLEAXPPASA-N
• SMILES: C=C1CCC2C(C)(C(=O)OC)CCCC2(C)C1CCC1=CCOC1=O
• 外观性状: 粉末
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.524
• 储存条件: 2-8℃，干燥，密闭

红松内酯安全信息

• 危害码 (欧洲): Xi

红松内酯靶点实验

查看更多实验

实验名称：Induction of membrane modification in erythrocytes assessed as formation of spherosto... 来源：ChEMBL 靶标：Erythrocyte External Id：CHEMBL1017631

实验名称：Induction of membrane modification in erythrocytes assessed as formation of discocyte... 来源：ChEMBL 靶标：Erythrocyte External Id：CHEMBL996356

实验名称：Antiplasmodial activity against Plasmodium falciparum 3D7 by [3H]phenylalanine uptake 来源：ChEMBL 靶标：Plasmodium falciparum External Id：CHEMBL1017630

实验名称：Allosteric modulation of gamma-aminobutyric acid receptor A alpha1beta2gamma2S expres... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2148432

实验名称：Allosteric modulation of gamma-aminobutyric acid receptor A alpha1beta2gamma2S expres... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2148431

实验名称：Induction of membrane modification in erythrocytes assessed as formation of stomatocy... 来源：ChEMBL 靶标：Erythrocyte External Id：CHEMBL996344

实验名称：Loss of mitochondrial membrane potential in human BJAB cells at 100 uM 来源：ChEMBL 靶标：BJAB External Id：CHEMBL865459

实验名称：Induction of mitochondrial permeability transition in human BJAB cells after 48 hrs 来源：ChEMBL 靶标：BJAB External Id：CHEMBL865461

实验名称：Induction of apoptosis in ALL cells at 100 uM after 60 hrs 来源：ChEMBL 靶标：Leukemia cell External Id：CHEMBL865464

实验名称：Induction of apoptosis in AML cells at 100 uM after 60 hrs 来源：ChEMBL 靶标：Leukemia cell External Id：CHEMBL865466

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红松内酯英文别名

• Methyl (1S,4aR,5S,8aR)-1,4a-dimethyl-6-methylene-5-[2-(2-oxo-2,5-dihydro-3-furanyl)ethyl]decahydro-1-naphthalenecarboxylate
• methyl (1S,4aR,5S,8aR)-1,4a-dimethyl-6-methylidene-5-[2-(2-oxo-2,5-dihydrofuran-3-yl)ethyl]decahydronaphthalene-1-carboxylate