SIB 1757

• 常用名: SIB 1757
• 英文名: SIB 1757
• CAS号: 31993-01-8
• 分子量: 213.24
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₂H₁₁N₃O
• 熔点: N/A
• 闪点: N/A

SIB 1757用途

SIB-1757是一种高选择性非竞争性mGlu5受体拮抗剂,IC50为0.4μM【1】。

SIB 1757名称

• 英文名: 6-methyl-2-(phenylhydrazinylidene)pyridin-3-one

SIB 1757生物活性

• 描述: SIB-1757是一种高选择性非竞争性mGlu5受体拮抗剂,IC50为0.4μM【1】。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 谷氨酸受体
  研究领域 >> 神经疾病
• 靶点实验:

  human mGluR5:0.4 μM (IC50)

• 参考文献:

  [1]. Varney MA, et al. SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5. J Pharmacol Exp Ther. 1999 Jul;290(1):170-81.

SIB 1757物理化学性质

• 分子式: C₁₂H₁₁N₃O
• 分子量: 213.24
• 精确质量: 213.09000
• PSA: 57.84000
• LogP: 3.51100
• InChIKey: LOCPVWIREQIGNQ-UHFFFAOYSA-N
• SMILES: Cc1ccc(O)c(N=Nc2ccccc2)n1
• 储存条件: -20°C， 密封， 干燥

SIB 1757安全信息

• 危害码 (欧洲): Xi
• 海关编码: 2933399090

SIB 1757海关

• 海关编码: 2933399090
• 中文概述: 2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
• Summary: 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

SIB 1757靶点实验

查看更多实验

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay 来源：ChEMBL 靶标：N/A External Id：CHEMBL1266185

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Inhibition of Photuris pyralis luciferase at 100 uM 来源：ChEMBL 靶标：Luciferin 4-monooxygenase External Id：CHEMBL935804

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Tocris HTS for Inhibitors of Aerobactin Synthetase lucA 来源：23265 External Id：IucA Pilot Assay Tocris Library

实验名称：Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based Syste... 来源：Broad Institute 靶标：N/A External Id：7124-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Dicer-mediated maturation of pre-microRNA 来源：Center for Chemical Genomics, University of Michigan 靶标：N/A External Id：TargetID_659_CEMA

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens] External Id：SIAE_INH_FP_1536_1X%INH PRUN

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SIB 1757英文别名

• 2-Benzoazo-6-methyl-3-hydroxypyridin
• 6-methyl-2-phenylazo-pyridin-3-ol