Fraxamoside

• 常用名: Fraxamoside
• 英文名: Fraxamoside
• CAS号: 326594-34-7
• 分子量: 538.50
• 密度: 1.5±0.1 g/cm3
• 沸点: 825.8±65.0 °C at 760 mmHg
• 分子式: C₂₅H₃₀O₁₃
• 熔点: N/A
• 闪点: 277.9±27.8 °C

Fraxamoside用途

Fraxamoside是一种竞争性黄嘌呤氧化酶抑制剂,IC50为16.1μM,Ki为0.9μM[1]。

Fraxamoside名称

• 英文名: Methyl (1S,3S,7S,12R,15R,16S,17S,18R,20E)-12-(3,4-dihydroxyphenyl)-20-ethylidene-16,17,18-trihydroxy-9-oxo-2,4,10,13,19-pentaoxatricyclo[13.3.1.13,7]icos-5-ene-6-carboxylate (non-preferred name)

Fraxamoside生物活性

• 描述: Fraxamoside是一种竞争性黄嘌呤氧化酶抑制剂,IC50为16.1μM,Ki为0.9μM[1]。
• 相关类别:
  研究领域 >> 代谢疾病
  信号通路 >> 代谢酶/蛋白酶 >> 黄嘌呤氧化酶
• 参考文献:

  [1]. Vitale RM, et al. Structure-activity relationships of fraxamoside as an unusual xanthine oxidase inhibitor. J Enzyme Inhib Med Chem. 2017 Dec;32(1):345-354.

Fraxamoside物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 825.8±65.0 °C at 760 mmHg
• 分子式: C₂₅H₃₀O₁₃
• 分子量: 538.50
• 闪点: 277.9±27.8 °C
• 精确质量: 538.168640
• PSA: 190.67000
• LogP: 1.26
• InChIKey: QVUZRUJONIJRDT-KGVSQERTSA-N
• SMILES: CC=C1C2OC=C(C(=O)OC)C1CC(=O)OCC(c1ccc(O)c(O)c1)OCC1OC(O2)C(O)C(O)C1O
• 外观性状: 粉末
• 蒸汽压: 0.0±3.2 mmHg at 25°C
• 折射率: 1.614
• 储存条件: 2-8℃，干燥，密闭

Fraxamoside安全信息

• 危害码 (欧洲): Xi

Fraxamoside靶点实验

查看更多实验

实验名称：Antiviral activity against Influenza A virus (A/WSN/1933(H1N1)) infected in MDCK cell... 来源：ChEMBL 靶标：Influenza A virus External Id：CHEMBL4223272

实验名称：Antiviral activity against Influenza A virus (A/WSN/1933(H1N1)) infected in MDCK cell... 来源：ChEMBL 靶标：Influenza A virus External Id：CHEMBL4223271

实验名称：Cytotoxicity against MDCK cells assessed as reduction in cell viability by CCK8 assay 来源：ChEMBL 靶标：MDCK External Id：CHEMBL4223273

实验名称：Antiviral activity against Influenza A virus (A/WSN/1933(H1N1)) infected in MDCK cell... 来源：ChEMBL 靶标：Influenza A virus External Id：CHEMBL4223270

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Fraxamoside英文别名

• Methyl (1S,3S,7S,12R,15R,16S,17S,18R,20E)-12-(3,4-dihydroxyphenyl)-20-ethylidene-16,17,18-trihydroxy-9-oxo-2,4,10,13,19-pentaoxatricyclo[13.3.1.1]icos-5-ene-6-carboxylate