Phortress

更新时间：2025-08-25 11:25:47

Phortress结构式	常用名	Phortress	英文名	Phortress
	CAS号	328087-38-3	分子量	459.408
	密度	N/A	沸点	N/A
	分子式	C₂₀H₂₅Cl₂FN₄OS	熔点	N/A
	MSDS	N/A	闪点	N/A

Phortress用途

荧光染料是一种高亲和力的AhR配体,通过诱导CYP1A1的转录诱导抗肿瘤活性[1][2]。

英文名	AXR52N9SMF
英文别名	更多

描述	荧光染料是一种高亲和力的AhR配体,通过诱导CYP1A1的转录诱导抗肿瘤活性[1][2]。
相关类别	研究领域 >> 癌症信号通路 >> 代谢酶/蛋白酶 >> 细胞色素P450
参考文献	[1]. Bradshaw TD, et al. In vitro evaluation of amino acid prodrugs of novel antitumour 2-(4-amino-3-methylphenyl)benzothiazoles. Br J Cancer. 2002 Apr 22;86(8):1348-54. [2]. Bradshaw TD, Westwell AD. The development of the antitumour benzothiazole prodrug, Phortress, as a clinical candidate. Curr Med Chem. 2004 Apr;11(8):1009-21.

描述

荧光染料是一种高亲和力的AhR配体,通过诱导CYP1A1的转录诱导抗肿瘤活性[1][2]。

相关类别

研究领域 >> 癌症

信号通路 >> 代谢酶/蛋白酶 >> 细胞色素P450

参考文献

[1]. Bradshaw TD, et al. In vitro evaluation of amino acid prodrugs of novel antitumour 2-(4-amino-3-methylphenyl)benzothiazoles. Br J Cancer. 2002 Apr 22;86(8):1348-54.

[2]. Bradshaw TD, Westwell AD. The development of the antitumour benzothiazole prodrug, Phortress, as a clinical candidate. Curr Med Chem. 2004 Apr;11(8):1009-21.

分子式	C₂₀H₂₅Cl₂FN₄OS
分子量	459.408
精确质量	458.111023
InChIKey	QZSMNTOCJVVFEU-CKUXDGONSA-N
SMILES	Cc1cc(-c2nc3cc(F)ccc3s2)ccc1NC(=O)C(N)CCCCN.Cl.Cl

实验名称：The compound was tested for its solubility at a pH of 10.5
来源：ChEMBL
靶标：N/A
External Id：CHEMBL636985

实验名称：The compound was tested for its solubility at a pH of 5.0
来源：ChEMBL
靶标：N/A
External Id：CHEMBL636986

实验名称：The compound was tested for its solubility at a pH of 6.3
来源：ChEMBL
靶标：N/A
External Id：CHEMBL636987

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER...
来源：ChEMBL
靶标：Severe acute respiratory syndrome coronavirus 2
External Id：CHEMBL4513082

实验名称：The compound was tested for its solubility at a pH of 7.4
来源：ChEMBL
靶标：N/A
External Id：CHEMBL636988

实验名称：The compound was tested for its solubility at a pH of 8.5
来源：ChEMBL
靶标：N/A
External Id：CHEMBL636989

实验名称：The compound was tested for its solubility at a pH of 9.6
来源：ChEMBL
靶标：N/A
External Id：CHEMBL636990

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac...
来源：ChEMBL
靶标：Severe acute respiratory syndrome coronavirus 2
External Id：CHEMBL4303805

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f...
来源：ChEMBL
靶标：Replicase polyprotein 1ab
External Id：CHEMBL4495582

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MFCD06407804

AXR52N9SMF

N-[4-(5-Fluoro-1,3-benzothiazol-2-yl)-2-methylphenyl]-L-lysinamide dihydrochloride

Hexanamide, 2,6-diamino-N-[4-(5-fluoro-2-benzothiazolyl)-2-methylphenyl]-, (2S)-, hydrochloride (1:2)